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ProteomicsA transcription factor from the cryptic Escherichia coli Rac prophage controls both phage and host operons
Bacterial genomes are shaped by cryptic prophages, which are viral genomes integrated into the bacterial chromosome. Escherichia coli genomes have 10 prophages on average. Though usually inactive, prophage genes can profoundly impact host cell physiology. Among the phage genes in the E. coli chromos...
ORGANISM(S): Escherichia coli 
2025-05-07 | PXD059580 | Pride
Proteomics Escherichia coli Rac prophage tf Ydat locus Dda Putative transcription factors 
ProteomicsEBI2/oxysterol signalling modulates the expression of VE-cadherin and attachment of multiple sclerosis CD4+ T cells to an in vitro blood-brain barrier model
Changes in the function of the blood-brain barrier (BBB) is one of the hallmarks of multiple sclerosis (MS) and is observed at very early stages of the disease. Several disease-modifying therapies for MS regulate tight junction and adherence proteins in the BBB thus limiting the entry of peripheral ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD055641 | Pride
Multiple sclerosis Human brain 
ProteomicsBeing spontaneous has its costs! Characterization of the spontaneous phage ϕD5-resistant mutants of Dickeya solani strain IPO 2222
Lytic bacteriophages able to infect and kill Dickeya spp. can be readily isolated from virtually all Dickeya spp.-containing environments, yet little is known about the selective pressure those viruses exert on their hosts. Here, we identified two spontaneous phage-resistant D. solani IPO 2222 mutan...
ORGANISM(S): Dickeya solani IPO 2222 
2023-04-28 | PXD038825 | Pride
Erwinia chrysanthemi Environmental fitness Phage resistance Fitness costs Ecology Potato 
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