A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...
Metabolomics has emerged as a mainstream approach for investigating the complex metabolic underpinnings of living systems. Over recent years, metabolomics has increasingly been applied to large cohort studies that tax the limits of existing computational tools. Though effective when applied ...
The metabolic network, composed of thousands of metabolic reactions, is essential for any organism. Despite its importance, a systems level understanding of how metabolic network is wired by reactions that carry flux in unperturbed condition and rewired by transcriptionally activating or repressi...