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TranscriptomicsChromatin immunoprecipitation of the MSL-1 and MSL-3 vs a mock IP in Drosophila and transcription profiling of X linked genes in WT male or female III instar larvae to provide X chromosome wide profiling of MSL-1 distribution and dosage compensation in Drosophila
Dosage compensation ensures that males and females, despite unequal number of X chromosomes, equalize for X linked gene expression. In Drosophila, it is achieved by a two-fold up-regulation of most of the genes present on the male X chromosome, and requires the association of the Dosage Compensation...
ORGANISM(S): Drosophila melanogaster 
2006-04-01 | E-MEXP-554 | biostudies-arrayexpress
TranscriptomicsMSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism
In Drosophila, X chromosome dosage compensation requires the male-specific lethal (MSL) complex, which associates with actively transcribed genes on the single male X chromosome to upregulate transcription approximately 2-fold. We found that on the male X chromosome, or when MSL complex is ectopical...
ORGANISM(S): Drosophila melanogaster 
2007-09-20 | E-GEOD-8557 | biostudies-arrayexpress
TranscriptomicsDrosophila MSL complex globally acetylates H4 Lys16 on the male X chromosome for dosage compensation
Drosophila MSL complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that ~25% of transcribed genes on the X do not stably recruit MSL complex. Here, we find that almost all active genes on the X are ...
ORGANISM(S): Drosophila melanogaster 
2009-06-10 | E-GEOD-14884 | biostudies-arrayexpress
GenomicsMOF-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation [ChIP-seq]
The histone acetyltransferase (HAT) Mof is essential for mouse embryonic stem cells (mESC) pluripotency and early development. Mof is the enzymatic subunit of two different HAT complexes, MSL (Male-Specific Lethal) and NSL (Non-specific lethal). The individual contribution of MSL and NSL complexes t...
ORGANISM(S): Mus musculus 
2014-06-04 | E-GEOD-53797 | biostudies-arrayexpress
GenomicsSAD-MSL
SAD-MSL Raw sequence reads
PRJNA1287472 | ENA
TranscriptomicsThe MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila
Active genes on the X chromosome of Drosophila males are upregulated by the Male-specific lethal (MSL) complex containing five MSL proteins and two non-coding roX RNAs. To probe the targeting mechanism, we have solved the structure of the MSL3 chromodomain, designed point mutations in key residues t...
ORGANISM(S): Drosophila melanogaster 
2008-11-18 | E-GEOD-11817 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of RNA associated to the MSL-complex in Drosophila melanogaster
In Drosophila, the global increase in transcription from the X chromosome in males to compensate for its monosomy is mediated by the male-specific-lethal complex (MSL-C) consisting of five proteins and two non-coding RNAs, roX1 and roX2. After an initial sequence dependent recognition by the MSL-C o...
ORGANISM(S): Drosophila melanogaster 
2011-04-13 | E-GEOD-20249 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse ES cells depleted of MOF, MSL1, MSL2 or KANSL3
We have studied the regulatory potential of MYST1-(MOF)-containing MSL and NSL complexes in mouse embryonic stem cells (ESCs) and neuronal progenitors. We find that both complexes influence transcription by binding to promoters as well as TSS-distal enhancer regions. In contrast to flies, the MSL co...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-57698 | biostudies-arrayexpress
GenomicsHomo sapiens strain:(MSL) Mende in Sierra Leone
Exome sequencing of (MSL) Mende in Sierra Leone HapMap population
PRJNA173702 | ENA
GenomicsHomo sapiens strain:(MSL) Mende in Sierra Leone
Whole genome sequencing of (MSL) Mende in Sierra Leone HapMap population
PRJNA173696 | ENA
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