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ProteomicsMice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009138 | Pride
Mtdna deletions Mgme1 knock out Progeria 
TranscriptomicsInsights into N-calls of mitochondrial DNA sequencing using MitoChip v2.0
Background: Developments in DNA resequencing microarrays include mitochondrial DNA (mtDNA) sequencing and mutation detection. During automated analysis to sequence mtDNA, bases can be identified as wildtype, variant, or there may be a failure to assign a base (N-call) when compared to the mtDNA refe...
ORGANISM(S): Homo sapiens 
2012-05-17 | E-GEOD-29550 | biostudies-arrayexpress
TranscriptomicsCells following mtDNA loss, or NAR1 repression
Expression analysis of cells the given amount of time after mtDNA was lost (or Nar1 expression was repressed) compared to pretreatment (or NAR1 being fully expressed). One time course experiment (Cells a given amount of time following mtDNA loss compared to cells with intact mtDNA), with 2 two condi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-21 | E-GEOD-15302 | biostudies-arrayexpress
GenomicsEngineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [DOGMAseq]
Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [DOGMAseq]
PRJNA1158748 | ENA
GenomicsEngineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [Exp1_iScaI_KL_T4]
Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [Exp1_iScaI_KL_T4]
PRJNA1158713 | ENA
GenomicsEngineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [Exp3_MGME1KO_KL_iApaLI]
Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [Exp3_MGME1KO_KL_iApaLI]
PRJNA1158718 | ENA
GenomicsEngineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [Exp2_POLGD274A_MGME1KO_ScaI]
Engineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [Exp2_POLGD274A_MGME1KO_ScaI]
PRJNA1158714 | ENA
TranscriptomicsEngineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [DOGMAseq]
Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled the precise introduction of base substitutions and the effective removal of genomes carrying harmful mutations. However, the reconstitution of mtDNA deletions responsible for severe mitochondrial disorders and...
ORGANISM(S): Homo sapiens 
2025-03-10 | GSE276718 | GEO
GenomicsEngineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [Exp3_MGME1KO_KL_iApaLI]
Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled the precise introduction of base substitutions and the effective removal of genomes carrying harmful mutations. However, the reconstitution of mtDNA deletions responsible for severe mitochondrial disorders and...
ORGANISM(S): Homo sapiens 
2025-03-10 | GSE276699 | GEO
GenomicsEngineering mtDNA Deletions by Reconstituting End-Joining in Human Mitochondria [Exp2_POLGD274A_MGME1KO_ScaI]
Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled the precise introduction of base substitutions and the effective removal of genomes carrying harmful mutations. However, the reconstitution of mtDNA deletions responsible for severe mitochondrial disorders and...
ORGANISM(S): Homo sapiens 
2025-03-10 | GSE276696 | GEO
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