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In general, yeast strains with myo1 knocked out cannot perform cytokinesis, but some evolve new ways of accomplishing the task. This is an examination of aneuploidies and CNVs in a selection of evolved mutants that can successfully perform cytokinesis. The purpose is to attempt a molecular charact...
ORGANISM(S): Saccharomyces cerevisiae 
We describe a simple method, Digital Restriction Enzyme Analysis of Methylation (DREAM), based on sequential DNA digestion with a pair of methylation-blocked and methylation-tolerant neoschizomeric restriction enzymes SmaI/XmaI followed by end repair and ultra-deep sequencing. DREAM provides informa...
ORGANISM(S): Homo sapiens 
Aneuploidy, the condition of having an abnormal number of chromosomes, is a hallmark of cancer cells. Recent work performed in yeast and mouse models suggests that aneuploidy interferes with cell proliferation and organism development. However, other recent experiments suggested that aneuploidy migh...
ORGANISM(S): Saccharomyces cerevisiae 
High-throughput secretomic analysis of single U937 cells.
2015-10-06 | LDS-1109 | LINCS
High-throughput secretomic analysis of single A549 cells.
2015-10-06 | LDS-1107 | LINCS
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