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TranscriptomicsTranscription profiling of liver from wild type and Hfe-/- mice with hereditary hemochromatosis subjected to dietary iron overload and treatment with nifedipine to reverse iron overload
Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues leading to eventual organ failure. We have discovered a novel mechanism to reverse iron overload by pharmacological modulation of the dival...
ORGANISM(S): Mus musculus 
2007-03-01 | E-MEXP-982 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse duodenum and liver with primary (Hfe ?/? and C282Y homozygous mice) and secondary iron overload vs 129S6/SvEvTac wild type controls
We determined duodenal and liver gene response patterns in mice with primary (Hfe ?/? and C282Y homozygous mice) and secondary iron overload versus 129S6/SvEvTac wild type controls.
ORGANISM(S): Mus musculus 
2013-01-30 | E-MEXP-5 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling from freshly harvested duodenums
Correlation of miRNA expression patterns with clinically relevant information is greatly facilitated by the retrospective analysis of samples archived in tissue banks. Unfortunately, the quality of samples stored in tissue banks is variable due to heterogeneity in pre-analytical preparation of clini...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-18774 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling from freshly harvested livers
Correlation of miRNA expression patterns with clinically relevant information is greatly facilitated by the retrospective analysis of samples archived in tissue banks. Unfortunately, the quality of samples stored in tissue banks is variable due to heterogeneity in pre-analytical preparation of clini...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-18775 | biostudies-arrayexpress
ModelsTiago2010_FeMetabolism_FeLoaded
This a model from the article: Systems analysis of iron metabolism: the network of iron pools and fluxes Tiago JS Lopes, Tatyana Luganskaja, Maja Vujic-Spasic, Matthias W Hentze, Martina U Muckenthaler, Klaus Schumann and Jens G Reich BMC Systems Biology2010, Aug 13;4...
2024-09-02 | BIOMD0000000261 | BioModels
ModelsTiago2010_FeMetabolism_FeAdequate
This a model from the article: Systems analysis of iron metabolism: the network of iron pools and fluxes Tiago JS Lopes, Tatyana Luganskaja, Maja Vujic-Spasic, Matthias W Hentze, Martina U Muckenthaler, K laus Schumann and Jens G Reich BMC Systems Biology2010, Aug 13;...
2024-09-02 | BIOMD0000000260 | BioModels
ModelsTiago2010_FeMetabolism_FeDeficient
This a model from the article: Systems analysis of iron metabolism: the network of iron pools and fluxes Tiago JS Lopes, Tatyana Luganskaja, Maja Vujic-Spasic, Matthias W Hentze, Martina U Muckenthaler, K laus Schumann and Jens G Reich BMC Systems Biology2010, Aug 13;...
2024-09-02 | BIOMD0000000259 | BioModels
TranscriptomicsmiRNA degradation in frozen tissue
To determine the effect of RNA degradation on miRNA expression profiling. To mimic total RNA degradation in snap-frozen livers and duodenums from mice (wild type female, C57/Bl6) tissues were stored in a -80°C freezer and then transferred to dry ice. Each frozen tissue was sliced into five identica...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-19104 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lipopolysaccharide-induced inflammation in HFE-deficient and wild types
Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is the anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron storage, resulting in low serum iron co...
ORGANISM(S): Mus musculus 
2004-03-15 | E-MEXP-95 | biostudies-arrayexpress
TranscriptomicsMYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44538 | biostudies-arrayexpress
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