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TranscriptomicsWild Type Tumor Repressor Protein 53 (TRP53) Promotes Ovarian Cancer Cell survival
Loss of Pten in the KrasG12D;Amhr2-Cre mutant mice leads to the transformation of ovarian surface epithelial (OSE) cells and rapid development of low-grade, invasive serous adenocarcinomas. Tumors occur with 100% penetrance and express elevated expression of wild type tumor repressor protein 53 (TRP...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-34882 | biostudies-arrayexpress
TranscriptomicsTumor repressor protein 53 and steroid hormones provide a new paradigm for ovarian cancer metastases
The functional status of the tumor repressor protein (TP53 or TRP53) is a defining feature of ovarian cancer. Mutant or null alleles of TP53 are expressed in greater than 90% of all high-grade serous adenocarcinomas. Wild type TP53 is elevated in low-grade serous adenocarcinomas in women and in our ...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-51095 | biostudies-arrayexpress
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