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TranscriptomicsGlobal expression analysis identified a preferentially NGF-induced transcriptional program regulated by sustained MEK/ERK and AP-1 activation during PC12 differentiation.
Neuronal differentiation of PC12 cells in response to NGF is a prototypical model in which signal duration determines a biological response. Sustained ERK activity induced by NGF, as compared to transient activity induced by EGF, is critical to the differentiation of these cells. To characterize the...
ORGANISM(S): Rattus norvegicus 
2011-11-13 | E-GEOD-33639 | biostudies-arrayexpress
TranscriptomicsImmediate-Early and Delayed Primary Response Genes are Distinct in Function and Genomic Architecture
Transcriptional profiling time course of serum deprived quiescent human T98G cells follwing platelet derived growth factor (PDGF) stimulation in the absence and presence of the translation inhibitor, cycloheximide. RNA was harvested at 0.5, 2, and 4 hr following PDGF treatment. Keywords: time cours...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-8315 | biostudies-arrayexpress
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