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MetabolomicsAdjunctive ibuprofen in pre-extensively drug-resistant and extensively drug-resistant tuberculosis: a Phase IIA open-label pilot clinical trial

Drug-resistant tuberculosis (TB) remains a major global health challenge. Host-directed therapies (HDTs) aim to limit tissue damage, shorten treatment, and improve outcomes by modulating immune responses. We evaluated the safety and potential efficacy of adjunctive ibuprofen an inexpens...

2026-05-28 | MTBLS13376 | MetaboLights
MetabolomicsMulti-Omics Elucidation of Cyclic Lipopeptide Pseudodesmin A-Mediated Biofilm eradication in Vancomycin-Resistant Enterococcus faecalis
In this study, we isolated and purified cyclic lipopeptide PDMA from our in-house strain Pseudomonas tolaasii ZTB4. We evaluated its antibacterial and antibiofilm activities against VREF, demonstrating that PDMA effectively eradicates mature biofilms. To decipher the mechanisms underlying this eradi...
2026-06-05 | MTBLS14677 | MetaboLights
Metabolomics1H HR-MAS NMR Based Metabolic Profiling of Cells in Response to Treatment with a Hexacationic Ruthenium Metallaprism as Potential Anticancer Drug
1H high resolution magic angle spinning (HR-MAS) NMR spectroscopy was applied in combination with multivariate statistical analyses to study the metabolic response of whole cells to the treatment with a hexacationic ruthenium metallaprism [1]6+ as potential anticancer drug. Human ovarian cancer cell...
2015-01-16 | MTBLS156 | MetaboLights
MetabolomicsThe killing mechanism of teixobactin against methicillin-resistant Staphylococcus aureus (MRSA): An untargeted metabolomics study

The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacteri...

2020-04-30 | MTBLS1569 | MetaboLights
TranscriptomicsIdentification of drug associated genes in ovarian cancer by RNA profiling
Two expression profilings were conducted in order to identify drug-associated genes in ovarian cancers. The first expression profiling was performed between RNAs from chemosensitive ovarian cancers and chemoresistant ovarian cancers. The second analysis was using a drug sensitive ovarian cancer cell...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-2058 | biostudies-arrayexpress
MetabolomicsDeciphering the Anti-Biofilm Mechanism of Anthraquinone-2-Carboxylic Acid Against MRSA by Comprehensive Multi-Omics Analysis

Background: Methicillin-resistant Staphylococcus aureus (MRSA) biofilms exhibit high levels of drug resistance and cause nosocomial infections in humans, thus posing a sustainable global health threat. This underscores the critical need to develop novel antibiofilm therapeutics with high efficacy...

2025-09-18 | MTBLS13012 | MetaboLights
MetabolomicsBiological Characteristics of SARS-CoV-2 Resistant Populations: A Cohort Comparison Study through Integrated Gut Microbiota Sequencing, Metabolomics and Proteomics

Objective: Most research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown. The study aimed to comprehensively analyze the differen...

2025-06-28 | MTBLS12654 | MetaboLights
TranscriptomicsInduction of 1C Aldoketoreductases and Other Drug Dose-dependent Genes Upon Acquisition of Anthracycline Resistance
Recent studies have suggested that elevated expression of aldoketoreductase (AKR) 1C1 or 1C2 in tumour cells is associated with increased resistance to DNA damaging agents such as cisplatin and doxorubicin. However, it has not been shown whether selection of tumour cells for resistance to DNA-damag...
ORGANISM(S): Homo sapiens 
2008-07-16 | E-GEOD-12115 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of Leishmania infantum methotrexate resistant strains using full-genome DNA microarrays
Transcriptional analysis of the drug resistant strain L. infantum MTX20.5 compared to the wild-type strain The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L. infantum Keywords: drug resistance Two-condition experiment, resistant strain MTX20.5 vs wild-type. Fo...
ORGANISM(S): Leishmania infantum 
2010-05-25 | E-GEOD-9947 | biostudies-arrayexpress
TranscriptomicsComparative Genomic Hybridization of Leishmania major methotrexate resistant strains vs wild-type LV39
CGH analysis of the drug resistant strain L. major MTX60.4 vs the wild-type strain LV39 The full-genome DNA microarrays includes one 70-oligonucleotides probe for each gene of L.major LV39 Keywords: drug resistance Two-condition experiment, resistant strain MTX60.4 vs wild-type LV39. Three biologic...
ORGANISM(S): Leishmania major 
2008-05-31 | E-GEOD-11623 | biostudies-arrayexpress
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