Sort   by:  
 Page size 
MetabolomicsSingle-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
TranscriptomicsSlug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU-treatment
In pancreatic cancer the survival rate is low, as the available treatment options usually only extend survival and seldom produce a cure. Drug resistance and disease reoccurrence is the typical reason for death after cancer diagnosis. 5-Fluorouracil (5-FU) is the main chemostatic used in first line ...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-58386 | biostudies-arrayexpress
TranscriptomicsProlonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics.
Background: Cancer stem cells are presumed to have virtually unlimited proliferative and self-renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with overexpression of ATP-binding cassette transporters. We investigated whether prolonged continuous selection of...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-24460 | biostudies-arrayexpress
TranscriptomicsClinical Relevance of Multidrug Resistance Gene Expression in Ovarian Serous Carcinoma Effusions
The presence of tumor cells in effusions within serosal cavities is a clinical manifestation of advanced-stage cancer and is generally associated with poor survival. Identifying molecular targets may help to design efficient treatments to eradicate these aggressive cancer cells and improve patient s...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-29702 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data from leukemia and breast cancer cell lines with/without treatment with microparticles
Microparticles (MPs) comprise the major source of systemic RNA including microRNA (miRNA), the aberrant expression of which appears to be associated with stage, progression and spread of many cancers. We have shown MPs to transfer multidrug resistance proteins accross both haematological and and non...
ORGANISM(S): Homo sapiens 
2012-06-08 | E-GEOD-34560 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cultured human ovarian cancer cells vincristine-sensitive parental ovarian tumor cell line (SKOV3) and its highly vincristine-resistant derivative
Gene expression profiles were assessed for vincristine-sensitive parental ovarian tumor cell line (SKOV3) and its highly vincristine-resistant derivative (SKVCR 2.0) Experiment Overall Design: Duplicate gene expression microarray experiments were undertaken for each of SKOV3 and SKVCR 2.0. Comparat...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7556 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of anthracycline-resistant breast cancer cell lines
Drug resistance in breast cancer is the major obstacle to a successful outcome following chemotherapy treatment. While upregulation of multidrug resistance (MDR) genes is a key component of drug resistance in multiple cancers, the complexity and hierarchy of non-MDR driven drug resistance pathways a...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-54326 | biostudies-arrayexpress
GenomicsOvercoming ABCB1 mediated multidrug resistance in castration resistant prostate cancer
Overcoming ABCB1 mediated multidrug resistance in castration resistant prostate cancer
PRJNA1129561 | ENA
UnknownMultidrug-resistant breast cancer: current perspectives.
Not available
S-EPMC3929252 | biostudies-literature
UnknownCombination Chemotherapy of Multidrug-resistant Early-stage Colon Cancer: Determining Optimal Dose Schedules by High-performance Computer Simulation.
Not available
S-EPMC9851383 | biostudies-literature
Sort   by:  
 Page size