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MetabolomicsHigh-throughput carotenoid profiling using multivariate curve resolution (Stability of isoprenoids in grape extract)
We present automated data analysis of high throughput high-performance liquid chromatography with diode array detection (HPLC-DAD) data using multivariate curve resolution. This technique provides spectra and elution profiles of all UV-Vis active compounds present in the mixture. The specifics of us...
2014-07-01 | MTBLS85 | MetaboLights
MetabolomicsMetabolite profiling in LC-DAD using multivariate curve resolution: the alsace package in R
For those chemical compounds absorbing in the UV–Vis region and not readily applicable to routine mass spectrometry ionisation methods, liquid chromatography coupled to diode array detection is a convenient platform to perform metabolite profiling. Data processing by hand is labour-intensive and err...
2014-07-01 | MTBLS86 | MetaboLights
MetabolomicsUntargeted food contaminant detection using UHPLC-HRMS combined with multivariate analysis: Feasibility study on tea (Dataset 2 - Validation)
Powerful data pretreatment strategies inspired from the field of metabolomics were adapted to chemical food safety context to enable samples discrimination by multivariate methods based on low abundance ions. A highly automated workflow was produced. The open-source XCMS package was used and efficie...
2018-10-26 | MTBLS754 | MetaboLights
MetabolomicsUntargeted food contaminant detection using UHPLC-HRMS combined with multivariate analysis: Feasibility study on tea (Dataset 1 - Development)
Powerful data pretreatment strategies inspired from the field of metabolomics were adapted to chemical food safety context to enable samples discrimination by multivariate methods based on low abundance ions. A highly automated workflow was produced. The open-source XCMS package was used and efficie...
2018-10-26 | MTBLS752 | MetaboLights
MetabolomicsDetection of adulteration in Iranian saffron samples by 1H NMR spectroscopy and multivariate data analysis techniques
Introduction: The high market value of saffron (Crocus sativus L.) has made it an attractive candidate for adulteration. Safflower (Carthamus tinctorius L.) and tartrazine are among the most common herbal and synthetic foreign materials that may be added to pure saffron for the purpose of adulterati...
2017-07-20 | MTBLS331 | MetaboLights
MetabolomicsComparative Analyses of Metabolomic Fingerprints and Cytotoxic Activities of Soft Corals from the Colombian Caribbean
Soft corals (Cnidaria, Anthozoa, Octocorallia) are a diverse group of marine invertebrates that inhabit various marine environments in tropical and subtropical areas. Several species are recognized as prolific sources of compounds with a wide array of biological activities. Recent advances in analyt...
2018-11-08 | MTBLS777 | MetaboLights
MetabolomicsIntegrated Transcriptomic and Metabolomic Analyses Reveal the Antibacterial Mechanism of Isocorydine against Mycobacterium bovis

Mycobacterium bovis, the causative agent of bovine tuberculosis, poses a significant zoonotic threat. This study defines the antibacterial activity and mechanism of the natural alkaloid isocorydine (ICD) against M. bovis using an integrated multi-omics approach. Phenotypic analyses demonstrated t...

2025-12-03 | MTBLS13441 | MetaboLights
Metabolomics1H NMR metabolomic and transcriptomic analyses reveal urinary metabolites as biomarker candidates in response to protein undernutrition in adult rats

BACKGROUND: Protein undernutrition is prevalent mainly among elderly people, and it could develop diseases such as sarcopenia. Urinary metabolites may become biomarkers reflecting protein undernutrition, but this has been insufficiently investigated.

OBJECTIVE:

2021-05-27 | MTBLS1452 | MetaboLights
MetabolomicsMulti-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis vinifera L.) Exposed to Water Deficit (Carotenoids; UPLC-DAD assay)

Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids...

2021-08-16 | MTBLS984 | MetaboLights
MetabolomicsMulti-omics analyses reveal regulatory networks underpinning metabolite biosynthesis in Nicotiana tabacum

Tobacco is a significant industrial crop, serving as a model for plant science and a promising specie for the production of proteins and small molecules. However, system biology studies of tobacco under natural field cultivation conditions remain scarce. Here, we construct a genome-scale metaboli...

2025-09-29 | MTBLS13071 | MetaboLights
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