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ProteomicsSND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically identified proteins bound to genomic and subgenomic SARS-CoV-2 RNAs. We find that the host protein SND1 binds the 5ʹ end o...
ORGANISM(S): Homo sapiens (Human) 
2023-10-05 | PXD037528 | Pride
Sars-cov-2 Rna-binding proteins Rna interactome 
TranscriptomicsCircular RNAs are a large class of animal RNAs with regulatory potency (PAR-CLIP)
Circular RNAs (circRNAs) in animals are an enigmatic class of RNAs with unknown function. To systematically explore circRNAs, we sequenced and computationally analyzed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, with oftentimes tissue/developmental stage ...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-43573 | biostudies-arrayexpress
UnknownComprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins.
Not available
S-EPMC4598758 | biostudies-literature
ProteomicsSHIFTR enables the unbiased identification of proteins bound to specific RNA regions in transcriptomes of virus and host
RNA-protein interactions determine the cellular fate of RNA and are central to regulating gene expression outcomes in health and disease. To date, no method exists to identify the proteins bound to specific regions in endogenous RNAs in an unbiased fashion. Here, we develop SHIFTR (Selective RNase-H...
ORGANISM(S): Homo sapiens (Human) 
2024-01-18 | PXD044722 | Pride
Interactomes Rna-protein interactions Virus-host interactions Sars-cov-2 Rna-binding proteins 
TranscriptomicsFMR1 targets distinct mRNA sequence elements to regulate protein expression [PAR-CLIP]
Fragile-X Syndrome (FXS) is a multi-organ disease leading to mental retardation, macro-orchidism in males, and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASD). FXS is typically caused by the loss of FRAGILE...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-39682 | biostudies-arrayexpress
TranscriptomicsFMR1 targets distinct mRNA sequence elements to regulate protein expression [Affymetrix]
Fragile-X Syndrome (FXS) is a multi-organ disease leading to mental retardation, macro-orchidism in males, and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASD). FXS is typically caused by the loss of FRAGILE...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-39504 | biostudies-arrayexpress
TranscriptomicsMOV10 is a 5' to 3' RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation Along 3' UTRs (PAR-CLIP)
RNA helicases are important regulators of gene expression that act by remodeling RNA secondary structures and as RNA-protein interactions. Here, we demonstrate that MOV10 has an ATP-dependent 5' to 3' in vitro RNA unwinding activity and determine the RNA-binding sites of MOV10 and its helicase mutan...
ORGANISM(S): Homo sapiens 
2014-04-11 | E-GEOD-48245 | biostudies-arrayexpress
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