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TranscriptomicsTranscriptome-wide identification of LARP4B binding sites in HEK293 cells
mRNAs are key molecules in gene expression and subject to diverse regulatory events. Regulation is accomplished by distinct sets of trans-acting factors that interact with mRNAs and form defined mRNA-protein complexes (mRNPs). The resulting “mRNP code” determines the fate of any given mRNA and thus ...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-69169 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (CEL PAR-CLIP)
Dicer is a deeply conserved endoribonuclease with key functions in small RNA biogenesis. Here we employed PAR-CLIP/iPAR-CLIP to identify direct Dicer binding sites in the transcriptomes of human cells and human. We found hundreds of novel miRNAs and non-canonical Dicer substrates with high sensitivi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-20 | E-GEOD-55325 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (HEK RNA-Seq)
Dicer is a deeply conserved endoribonuclease with key functions in small RNA biogenesis. Here we employed PAR-CLIP/iPAR-CLIP to identify direct Dicer binding sites in the transcriptomes of human cells and human. We found hundreds of novel miRNAs and non-canonical Dicer substrates with high sensitivi...
ORGANISM(S): Homo sapiens 
2014-11-20 | E-GEOD-55326 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (HEK PAR-CLIP)
Dicer is a deeply conserved endoribonuclease with key functions in small RNA biogenesis. Here we employed PAR-CLIP/iPAR-CLIP to identify direct Dicer binding sites in the transcriptomes of human cells and human. We found hundreds of novel miRNAs and non-canonical Dicer substrates with high sensitivi...
ORGANISM(S): Homo sapiens 
2014-11-20 | E-GEOD-55324 | biostudies-arrayexpress
TranscriptomicsA variety of Dicer substrates in human and C. elegans (HEK small RNA)
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been directly mapped. Here, we apply biochemical methods to human cells and C. elegans and identify thousands of Dicer binding site...
ORGANISM(S): Homo sapiens 
2014-11-20 | E-GEOD-63458 | biostudies-arrayexpress
TranscriptomicsA variety of Dicer substrates in human and C. elegans (CEL RNA-seq)
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been directly mapped. Here, we apply biochemical methods to human cells and C. elegans and identify thousands of Dicer binding site...
ORGANISM(S): Caenorhabditis elegans 
2014-11-20 | E-GEOD-63435 | biostudies-arrayexpress
TranscriptomicsA variety of Dicer substrates in human and C. elegans (HEK RNA-seq)
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been directly mapped. Here, we apply biochemical methods to human cells and C. elegans and identify thousands of Dicer binding site...
ORGANISM(S): Homo sapiens 
2014-11-20 | E-GEOD-63475 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (CEL RNA-Seq)
Dicer is a deeply conserved endoribonuclease with key functions in small RNA biogenesis. Here we employed PAR-CLIP/iPAR-CLIP to identify direct Dicer binding sites in the transcriptomes of human cells and C.elegans. We found hundreds of novel miRNAs and non-canonical Dicer substrates with high sensi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-20 | E-GEOD-55329 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (small RNA AGO-IP)
Dicer is a deeply conserved endoribonuclease with key functions in small RNA biogenesis. Here we employed PAR-CLIP/iPAR-CLIP to identify direct Dicer binding sites in the transcriptomes of human cells and human. We found hundreds of novel miRNAs and non-canonical Dicer substrates with high sensitivi...
ORGANISM(S): Homo sapiens 
2014-11-20 | E-GEOD-55331 | biostudies-arrayexpress
TranscriptomicsTranscriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (CEL small RNA)
Dicer is a deeply conserved endoribonuclease with key functions in small RNA biogenesis. Here we employed PAR-CLIP/iPAR-CLIP to identify direct Dicer binding sites in the transcriptomes of human cells and human. We found hundreds of novel miRNAs and non-canonical Dicer substrates with high sensitivi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-20 | E-GEOD-55332 | biostudies-arrayexpress
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