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ProteomicsTotal protein abundances upon Mcm6 knockdown in the murine CH12 cells
Chromosomal translocations result from joining of DNA double-strand breaks (DSBs) and frequently cause cancer. Yet, the steps linking DSB formation to DSB ligation remain undeciphered. We report that DNA replication timing (RT) directly regulates lymphomagenic Myc translocations during antibody matu...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-13 | PXD034446 | Pride
Murine ch12 cells Mcm6 knockdown Protein abundance 
ProteomicsIdentification of TFG- and autophagy-regulated proteins and glycerophospholipids in B cells shows a role for TFG in metabolism
Autophagy supervises proteostasis and survival of plasma cells. TFG (Trk-fused gene) promotes autophagosome-lysosome flux in murine CH12 B cells, as well as their survival. Moreover, TFG is abundant in plasma cells. Hence, quantitative proteomics of CH12tfgKO and WT B cells in combination with lyso...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-27 | PXD039180 | Pride
Autophagy  autophagy flux  lysosome  b cell  endoplasmic reticulum stress  ribosome  immunoglobulin  plasma cell  jchain  trk-fused gene  phosphatidylglycerol 
UnknownGenome instability and transcription elongation impairment in human cells depleted of THO/TREX.
Not available
S-EPMC3228816 | biostudies-literature
UnknownIdentification of TFG- and Autophagy-Regulated Proteins and Glycerophospholipids in B Cells.
Not available
S-EPMC11077586 | biostudies-literature
UnknownAn inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex.
Not available
S-EPMC4382329 | biostudies-literature
UnknownThe AhR and NF-κB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3' Immunoglobulin Heavy Chain Regulatory Region.
Not available
S-EPMC5009439 | biostudies-literature
OtherIdentification of genes involved in class switch recombination by genome-wide CRISPR/Cas9 knock-out screen
This screen aims to identify genes involved in class switch recombination (CSR), a process that allows B cells to change the isotype they express from IgM/IgD to IgG, IgA or IgE. For that purpose, the murine B cell line CH12 stably expressing Cas9 was used. This cell line can be induced to undergo C...
ORGANISM(S): Mus musculus 
2021-09-18 | GSE184145 | GEO
GenomicsIdentification of genes involved in class switch recombination by genome-wide CRISPR/Cas9 knock-out screen
Identification of genes involved in class switch recombination by genome-wide CRISPR/Cas9 knock-out screen
PRJNA763368 | ENA
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