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MetabolomicsMetabolic reprogramming is an initial step in pancreatic carcinogenesis that can be targeted to inhibit acinar-to-ductal metaplasia

Metabolic reprogramming is a hallmark of cancer and is crucial for cancer progression, making it an attractive therapeutic target. Understanding the role of metabolic reprogramming in cancer initiation could help identify prevention strategies. To address this, we investigated metabolism during a...

2024-05-31 | MTBLS9772 | MetaboLights
TranscriptomicsTranscriptional profiling of mouse pancreatic beta-cells, embryonic stem cells and 10 other normal adult tissues.
To gain insights into how pancreatic beta-cells are programmed in vivo, we profiled key histone methylations (H3K4/K27me3) in embryonic stem cells, multipotent progenitors of the nascent embryonic pancreas, purified beta-cells, and 10 other adult tissues (all under normal, untreated conditions). For...
ORGANISM(S): Mus musculus 
2010-03-19 | E-TABM-877 | biostudies-arrayexpress
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD057798 | Pride
Murine normal pancreatic tissue 
TranscriptomicsPancreatic Tumor vs Various Tissue Normals
Pancreatic Tumor samples from biopsy collected at different stages along with normal tissue samples from various organ sites including commercial normals arrayed on 2channel Agilent 60mer Oligo arrays (human v1 & v2), median normalized for cross comparison. Some normal samples temporarily removed to...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-11838 | biostudies-arrayexpress
GenomicsCU37_WES of paired murine PKCY and A3A PKCY tumors and normal tissue
We aimed to decipher human APOBEC3A driven mutational differences in pancreatic tumor in vivo using a genetically engineered mouse model of pancreatic cancer. Murine pancreatic tumor formation was driven by p53fl/+;KrasLSL-G12D/+;Pdx1-Cre;Rosa26LSL-YFP (PKCY) and p53fl/+;KrasLSL-G12D/+;Pdx1-Cre; Ro...
ORGANISM(S): Mus musculus 
2021-09-06 | E-MTAB-9972 | biostudies-arrayexpress
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD057795 | Pride
Murine pdac tumor 
ProteomicsProteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10-15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based system modelling to generate multimodal datasets from various re...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-18 | PXD057793 | Pride
Murine pdac cells 
TranscriptomicsAffymetrix Arrays Interrogated with Tumor/Normal Pancreatic Samples
To identify genes in the chromosome 3p12 pathway to tumorigenesis in pancreatic cancer, we screened two expression platforms and then as a third platform interrogated pancreatic cancer tumor/normal samples for differential expression. Data from the third expression platform experiments are shown he...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-22780 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse pancreatic beta-cells.
To gain insights into how pancreatic beta-cells are programmed in vivo, we profiled key histone methylations (H3K4/K27me3) in embryonic stem cells, multipotent progenitors of the nascent embryonic pancreas, purified beta-cells, and 10 other adult tissues (all under normal, untreated conditions). For...
ORGANISM(S): Mus musculus 
2010-03-19 | E-TABM-906 | biostudies-arrayexpress
TranscriptomicsPancreatic Cancer 1
This is the experiment set used for a paper written in collaboration with Hopkins. It compares genes that are differentially expressed between normal pancreas, pancreatic cell lines and pancreatic adenocarcinoma. Pancreatic cancer is the fifth leading cause of cancer death in the United States. We u...
ORGANISM(S): Homo sapiens 
2005-11-23 | E-GEOD-3654 | biostudies-arrayexpress
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