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TranscriptomicsTranscription profiling of skeletal and cardiac muscles in dysferlin-deficient SJL/J mice and wild type mice to understand the protective mechanisms against dysferlin deficiency in cardiac muscles.
Dysferlin is expressed in skeletal and cardiac muscle. However, dysferlin deficiency, namely limb girdle muscular dystrophy 2B (LGMD2B) and Myoshi myopathy, results in skeletal muscle weakness and spares the heart. This dichotomy could be caused by differential regulation of protective mechanisms. T...
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2507 | biostudies-arrayexpress
TranscriptomicsExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
The Murphy Roth Large (MRL) mouse, a strain capable of regenerating right ventricular myocardium, has a high post-myocardial infarction (MI) survival rate compared with C57BL6/J (C57) mice. The biological processes responsible for this survival advantage are unknown. We compared acute post-MI gene e...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-19322 | biostudies-arrayexpress
ProteomicsSubversion of kynurenine-induced AHR activation in CD8 T cells by kynureninase-expressing antigen presenting cells
Kynurenine, an intermediate metabolite of tryptophan metabolism, suppresses the antitumor activity of CD8+ T cells by activating the aryl hydrocarbon receptor (AHR). Its role in adaptive immunity is poorly understood. Outside the liver, kynurenine is mainly produced by indoleamine 2,3-dioxygenase 1 ...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD074605 | Pride
Macrophages 
UnknownLymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.
Not available
S-EPMC2630261 | biostudies-literature
UnknownEarly postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background.
Not available
S-EPMC3253239 | biostudies-literature
UnknownElements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.
Not available
S-EPMC3009784 | biostudies-literature
UnknownAberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.
Not available
S-EPMC2234053 | biostudies-literature
UnknownMINMON-J: a hybrid implementation pilot study evaluating a low-barrier hepatitis C treatment model in a jail setting.
Not available
S-EPMC12506189 | biostudies-literature
TranscriptomicsExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
The Murphy Roth Large (MRL) mouse, a strain capable of regenerating right ventricular myocardium, has a high post-myocardial infarction (MI) survival rate compared with C57BL6/J (C57) mice. The biological processes responsible for this survival advantage are unknown. We compared acute post-MI gene e...
ORGANISM(S): Mus musculus 
2010-05-01 | GSE19322 | GEO
TranscriptomicsPQM-1 and Cobalt Chloride dependent gene expression changes in C. elegans
Worms were exposed to 5 mM CoCl2 at the early day 1 of adulthood stage for 6 hr and 20 hr. Untreated worms were used as controls. Worms were collected, RNA isolated and hybridized on 4x44K C. elegans arrays (Agilent) at 60C overnight, as previously described 1). Three biological replicates were used...
ORGANISM(S): Caenorhabditis elegans 
2020-07-08 | GSE139562 | GEO
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