Sort   by:  
 Page size 
TranscriptomicsIdentification of gene targets of Meis1
The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Our present study suggested it exerts two distinguishable effects in differentiating ES cells. First, it increases the numbers of hematopoietic progenitors and extends their persiste...
ORGANISM(S): Mus musculus 
2012-08-02 | E-GEOD-34543 | biostudies-arrayexpress
TranscriptomicsIdentification of gene targets of Meis2
The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Meis2, another member of the same family, shares 82% protein identities with Meis1. Our present study suggested Meis2 exerts two distinguishable effects in differentiating ES cells. ...
ORGANISM(S): Mus musculus 
2012-08-02 | E-GEOD-34541 | biostudies-arrayexpress
GenomicsBATF-JUN is critical for IRF4-mediated transcription in T cells
Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cell...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-39756 | biostudies-arrayexpress
TranscriptomicsMesp1 induces a subset of hematopoietic-associated transcription factors in ES cell-derived Flk1+Tie2+ endothelium
Previously, we reported that the transcription factor Mesp1 promotes the cell fates of cardiomyocytes, smooth muscle, and vascular endothelium. Recently, hematopoietic stem cells (HSCs) were shown to derive from hemogenic endothelium. Since Mesp1 regulates development of endothelium, it potentially...
ORGANISM(S): Mus musculus 
2012-08-02 | E-GEOD-34537 | biostudies-arrayexpress
TranscriptomicsExpression data from differentiating Flk1- and Flk1+ ES cells expressing Snail during Wnt inhibition
ES cells differentiated in the presence of the Wnt inhibitor DKK1 fail to express the transcription factor Snail and undergo EMT or mesoderm differentiation. We generated an ES cell line, A2.snail, that induced Snail expression upon addition of doxycycline addition. Microarrays were used to gain a ...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-26524 | biostudies-arrayexpress
GenomicsL-Myc expression by dendritic cells is required for optimal T-cell priming
The transcription factor IRF8 is a critical regulator of plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development in both mouse and man. Yet the downstream molecular targets that regulate DC homeostasis and development are largely unknown. A recent study using gene expressi...
ORGANISM(S): Mus musculus 
2013-12-14 | E-GEOD-53311 | biostudies-arrayexpress
UnknownAn immunohistochemical atlas of necroptotic pathway expression.
Not available
S-EPMC11250867 | biostudies-literature
Sort   by:  
 Page size