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UnknownLoss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation.
Not available
S-EPMC7931370 | biostudies-literature
ProteomicsZebrafish 24hpf whole embryo MZezh2mutant
Polycomb group (PcG) proteins are transcriptional repressors important to maintain cell identity during embryonic development. Ezh2, the catalytic subunit of the Polycomb Repressive Complex 2, is responsible for placing the epigenetic repressive mark histone H3 lysine 27 trimethylation (H3K27me3). I...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-09-09 | PXD010922 | Pride
Embryo 24hpf Zebrafish Ezh2 
TranscriptomicsGlobal Run-On sequencing (GRO-seq) of HeLa cells under CDK9 inhibitor tratment to study elongation checkpoints at both ends of RNA polymerase II-transcribed genes.
Global Run-On sequencing (GRO-seq) was carried out on nuclei isolated from HeLa cells after 30 minutes of treatment with CDK9 inhibitors KM05382 and DRB and from two untreated controls. Libraries of nascent RNAs were generated and sequenced using Illumina Hi-seq technology. GRO-seq reads were proces...
ORGANISM(S): Homo sapiens 
2015-02-26 | E-MTAB-3360 | biostudies-arrayexpress
GenomicsLoss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
DNA methylation at the 5-position of cytosine (5-mC) is a key epigenetic mark critical for varius biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the Ten-Eleven Translocation (TET) family of DNA hydroxylases. Here we report that "loss of 5-hmC&...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-38231 | biostudies-arrayexpress
UnknownMaintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan.
Not available
S-EPMC6803366 | biostudies-literature
TranscriptomicsGene expression analysis in a variety of normal, premalignant and squamous cell carcinomas of the cervix
We sought to apply the technologies of gene expression profiling to detect genes significant in the aetiology of cervical carcinoma . We investigated 14 normal (NAD), 11 low grade squamous intrapepithelial lesions (LSIL), 21 high grade squamous intraepithelial lesions (HSIL) and 28 squamous cell ca...
ORGANISM(S): Homo sapiens 
2013-09-17 | E-GEOD-27678 | biostudies-arrayexpress
TranscriptomicsExpression data from uterine endometrial tissues of Holstein-Friesian cows on days 14-16 after calving
Most dairy cows suffer uterine microbial contamination postpartum. Persistent endometritis often develops, associated with reduced fertility. We used a model of differential feeding and milking regimes to produce cows in differing negative energy balance (NEB) status in early lactation. We used Affy...
ORGANISM(S): Bos taurus 
2009-04-04 | E-GEOD-15544 | biostudies-arrayexpress
UnknownMapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness.
Not available
S-EPMC7419015 | biostudies-literature
UnknownA bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes.
Not available
S-EPMC6158172 | biostudies-literature
UnknownTumor Junction Burden and Antigen Presentation as Predictors of Survival in Mesothelioma Treated With Immune Checkpoint Inhibitors.
Not available
S-EPMC8882146 | biostudies-literature
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