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Hereditary Spastic Paraplegia (HSP) leads to progressive gait disturbances with lower limb muscle weakness and spasticity. Mutations in SPG4 are a major cause of autosomal-dominant HSP. Spastin, the protein encoded by SPG4, is a microtubule-severing protein and is enriched in the distal axon of cor...
ORGANISM(S): Homo sapiens 
Nasal biopsies were collected from control and A-T patients prior to establishing olfactory neurosphere derived (ONS) cells. These cells were phenotyped using stem cell markers, a series of A-T cellular characteristics determined and cells differentiated into neuronal cells.
ORGANISM(S): Homo sapiens 
Physiologically relevant cellular models are critical for understanding complex pathological processes. Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterised by motor and non-motor symptoms. Several cellular models for PD have been developed to reproduce the a...
ORGANISM(S): Homo sapiens 
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
Tissue repair using cell transplantation holds popular appeal. This underlines the need to understand stem cells within the target organ. Our laboratory works on the human brain. Using neurosphere methods, we and others have only been able to passage stem/progenitors a very few times with little exp...
ORGANISM(S): Homo sapiens 
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