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TranscriptomicsProfiling wt SOD versus ALS SOD1(G93A) mutant
Whole-genome profiling of SH-SY5Y cells was done on neuroblastoma SH-SY5Y stably transfected with cDNAs coding for SOD1WT or the mutant SOD1(G93A) protein. Five wt SOD versus five mutant SOD
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21298 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in fast and slow skeletal muscle of wild type and SOD1-G93A mice
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease that progressively debilitates neuronal cells that control voluntary muscle activity. In a mouse model of ALS that expresses mutated human superoxide dismutase 1 (SOD1-G93A) skeletal muscle is one of the tissues affected early by m...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-55507 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of primary astrocytes expressing ALS-linked mutant SOD1.
Amyotrophic lateral sclerosis (ALS) is caused by the progressive degeneration of motor neurons. Mutations in the Cu/Zn superoxide dismutase (SOD1) are found in about 20% of patients with familial ALS. Mutant SOD1 causes motor neuron death through an acquired toxic property. Although, molecular mecha...
ORGANISM(S): Rattus norvegicus 
2008-12-18 | E-GEOD-7441 | biostudies-arrayexpress
TranscriptomicsPathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1
Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neural degeneration. Here, we have combined reprogramming...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-54409 | biostudies-arrayexpress
TranscriptomicsTranscriptome Profiling following Neuronal and Glial Expression of ALS-linked SOD1 in Drosophila
Amyotrophic Lateral Sclerosis (ALS) is generally a late onset neurodegenerative disease. Mutations in the Cu/Zn superoxide dismutase 1 (SOD1) gene accounts for approximately 20% of familial ALS and 2% of all ALS cases. Although a number of hypothesis have been proposed to explain mutant SOD1 toxic...
ORGANISM(S): Drosophila melanogaster 
2012-06-30 | E-GEOD-37148 | biostudies-arrayexpress
GenomicsSOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells
SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells
PRJNA1005625 | ENA
TranscriptomicsTranslational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
Ubiquitous expression of ALS-causing mutations in superoxide dismutase 1 (SOD1) provoke non-cell autonomous paralytic disease. By combining ribosome affinity purification and high-throughput sequencing, a cascade of mutant SOD1-dependent, cell type-specific changes are now identified. Initial mutant...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-74724 | biostudies-arrayexpress
TranscriptomicsMutant SOD1 rats (lobsi-affy-rat-194438)
Missense mutations in the gene for the ubiquitously expressed superoxide dismutase-1 (SOD1) are one of the causes of familial amyotrophic lateral sclerosis (ALS), the most common adult onset motor neuron disease in humans killing selectively large motor neurons. Mice and rats overexpressing mutant S...
ORGANISM(S): Rattus norvegicus 
2007-04-11 | GSE7493 | GEO
TranscriptomicsMouse ES-derived motor neurons (ES-MN) exposed to SOD1 mutant mouse astrocyte conditioned media
This datased was used to obtain a genome-wide expression signature for the early response of mouse motor neurons to mutant SOD1 astrocytes conditioned media. Neurons, far from living in isolation, are surrounded by a host of other neuronal and non-neuronal cells, such as astrocytes. The latter enter...
ORGANISM(S): Mus musculus 
2014-12-17 | E-GEOD-49023 | biostudies-arrayexpress
UnknownAnti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons.
Not available
S-EPMC9784173 | biostudies-literature
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