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TranscriptomicsMito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice
Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a failure of normal mitochondrial quality-control syste...
ORGANISM(S): Mus musculus 
2015-04-21 | E-GEOD-57761 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Aged Polg Mutator Mouse Brains
We have performed both proteomic and transcriptomic analyses of the brains of one-year old Polg mutator mice. As part of this analysis, we generated RNA-Seq data from RNA isolated from one cerebral hemisphere of these mice. mRNA levels and protein abundance levels were compared in this study. 11 sa...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-55188 | biostudies-arrayexpress
GenomicsA Tudor-domain containing protein, SIMR-1, mediates silencing of piRNA target mRNAs by the Mutator Complex
A Tudor-domain containing protein, SIMR-1, mediates silencing of piRNA target mRNAs by the Mutator Complex
PRJNA575051 | ENA
TranscriptomicsA Tudor-domain containing protein, SIMR-1, mediates silencing of piRNA target mRNAs by the Mutator Complex
piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, silencing of piRNA target genes is mediated by the Mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA-dependent RNA polymerase. However, how mRNAs re...
ORGANISM(S): Caenorhabditis elegans 
2020-04-27 | GSE138220 | GEO
ProteomicsSubcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of compromised mitochondrial DNA repair.
The mitochondrial mutator mouse is a well-established model of premature aging in which a progeroid phenotype is driven by the accumulation of somatic mtDNA mutations. Despite evidence of bioenergetic disruption within the cardiac mitochondria, there is little information about the underlying change...
ORGANISM(S): Mus Musculus (mouse) 
2021-01-08 | PXD017000 | JPOST Repository
TranscriptomicsTranscription profiling of mouse cochlea to investigate the role of mtDNA mutations in age-related hearing loss in mice carrying a mutator DNA polymerase gamma
Mitochondrial DNA (mtDNA) mutations may contribute to aging and age-related disorders. Previously, we created mice expressing a proofreading-deficient version of the mtDNA polymerase gamma (Polg) which accumulate age-related mtDNA mutations and display premature aging. Here we performed microarray g...
ORGANISM(S): Mus musculus 
2008-11-07 | E-GEOD-4866 | biostudies-arrayexpress
UnknownDistinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci.
Not available
S-EPMC6072111 | biostudies-literature
TranscriptomicsRNA-seq of E.coli wild-type strain
We create mutator protein, MutaEco. To comprehensive analyze the correlation between the expression level and the mutation level.
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2021-08-21 | E-MTAB-10852 | biostudies-arrayexpress
UnknownEpistasis between mutator alleles contributes to germline mutation spectra variability in laboratory mice.
Not available
S-EPMC10168256 | biostudies-literature
UnknownEpistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice.
Not available
S-EPMC10942616 | biostudies-literature
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