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TranscriptomicsReaeration timecourse from a defined hypoxia model
Reaeration timecourse from a defined hypoxia model in Mycobacterium tuberculosis. The mechanism by which mycobacteria return to a replicating state upon re-exposure to favorable conditions is not well understood. In this study, we utilized reaeration from a defined hypoxia model to characterize the...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-28 | E-GEOD-21590 | biostudies-arrayexpress
TranscriptomicsFunctional Genomics Reveals Extended Roles of the Mycobacterium tuberculosis Stress Response Factor sigmaH
DNA Microarray based comparison of M. tuberculosis and its isogenic delta-sigmaH mutant for an extended period of time, using a diamide-stress and removal strategy (post-diamide stress or PDS) Raw data has been requested of, but not provided by, the submitter. Two strains, M. tuberculosis vs delta-...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-24 | E-GEOD-15608 | biostudies-arrayexpress
TranscriptomicsThe Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy
The isogenic Mtb:ΔRv2745c mutant is significantly more sensitive normoxia conditions after a period of hypoxia, relative to wild-type Mtb, implicating a role for ClgR in response to reactivation, in vivo. Both hypoxia and reaeration treatment led to dysregulation of the σH regulon in the isogenic mu...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2014-12-12 | E-GEOD-64065 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Mycobacterium tuberculosis clp gene regulator (ClgR) mutants
Data is also available from BuG@Sbase
ORGANISM(S): Mycobacterium tuberculosis 
2010-10-08 | E-BUGS-96 | biostudies-arrayexpress
ProteomicsProteomic Profiling of Mycobacterium tuberculosis in Response to ILE Treatment
This study aims to elucidate the global proteomic changes in Mycobacterium tuberculosis upon treatment with the novel compound ilamycin E(ILE), which targets the Clp protease system. Label-free quantitative proteomics was employed to assess differential protein expression after ILE exposure. The res...
ORGANISM(S): Mycobacterium tuberculosis H37Ra 
2026-02-09 | PXD066355 | Pride
Mycobacterium tuberculosis Tuberculosis Ilamycin e 
ProteomicsEffect of depletion of clpP2, clpX and clpC1 genes on whole cell proteome profile of Mycobacterium tuberculosis H37Rv
Global protein alteration in Mycobacterium tuberculosis H37 RV ( Mtb-H37RV) having depletion of Clpx ,Clp2 and ClpC1 were accessed using 4 plex iTRAQ label.
ORGANISM(S): Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis 
2020-05-14 | PXD013589 | Pride
Mycobacterium clp 
ProteomicsEffect of loss of clpP2, clpX and clpC1 genes on proteome of Mycobacterium tuberculosis.
The current work involves the quantitative analysis of total proteome of M. tuberculosis H37Rv depleted with the expression of different clp genes viz., clpP2, clpX and clpC1, respectively, by iTRAQ. Silencing of these genes was performed by CRISPRi approach by co-expression of specific guide sequen...
ORGANISM(S): Mycobacterium 
2020-03-20 | PXD013156 | JPOST Repository
ProteomicsAnalysis of the effect of ClpC1 directed antibiotics on ClpC1, ClpC2 and ClpC3 protein levels.
Ecumicin and Cyclomarin A (CymA) are known antimicrobial compounds that target the NTD of ClpC1. In proteomics analysis of compound treated M. smegmatis, two novel protein, ClpC2 and ClpC3, have been identified as strong interactors of those compounds in addition to ClpC1. In this study we used PRM ...
ORGANISM(S): Mycolicibacterium Smegmatis 
PXD037198 | panorama
TranscriptomicsThe Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy
The isogenic Mtb:ΔRv2745c mutant is significantly more sensitive normoxia conditions after a period of hypoxia, relative to wild-type Mtb, implicating a role for ClgR in response to reactivation, in vivo. Both hypoxia and reaeration treatment led to dysregulation of the σH regulon in the isogenic mu...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 Mycobacterium tuberculosis H37Rv 
2014-12-12 | GSE64065 | GEO
GenomicsMycobacterium tuberculosis CDC1551
The Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy
PRJNA270020 | ENA
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