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MetabolomicsMetabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry
Myelin is a natural and dynamic multilamellar membrane structure that continues to be of significant biological and neurological interest, especially with respect to its biosynthesis and assembly during its normal formation and maintenance, and pathological breakdown. To explore the usefulness of ne...
2024-09-27 | MTBLS4717 | MetaboLights
TranscriptomicsThe transcriptome of central nervous system myelin
Rapid nerve conduction in the CNS is facilitated by the insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics is not well understood. Hypo...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-78151 | biostudies-arrayexpress
ProteomicsAltered turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35
Fatty acid 2-hydroxylase (FA2H) is responsible for the synthesis of 2-hydroxylated fatty acids, which are a building block of sphingolipids. This 2-hydroxylated sphingolipids can be found in various tissues such as brain, spinal cord, skin, testis, ovary, kidney, stomach, or intestine with a notably...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021021 | Pride
Cns Mice Hereditary spastic paraplegia 35 Sphingolipids Neurodegeneration Disease model Fa2h Tmt Time course Myelin Fatty acid hydroxylation Isobaric labeling Fatty acid 2-hydroxylase Opalin 
ProteomicsWhite matter integrity requires continuous myelin synthesis at the inner tongue
Myelin, the electrically insulating axonal sheath, is composed of lipids and proteins with exceptionally long lifetime. Using 3D electron microscopy, mass spectrometry imaging, and quantitative proteome analysis, we addressed the question how myelin function is affected by myelin turnover. We studie...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-14 | PXD025180 | Pride
Shiverer Myelin basic protein (mbp) Myelinoid body Juxtaparanode Myelin turnover Whole optic nerve proteome Optic nerve Fib-sem 3d reconstruction Nanosims 
UnknownActin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.
Not available
S-EPMC4736019 | biostudies-literature
UnknownOligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death.
Not available
S-EPMC9639605 | biostudies-literature
UnknownRab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.
Not available
S-EPMC7275063 | biostudies-literature
UnknownLoss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover.
Not available
S-EPMC11496662 | biostudies-literature
TranscriptomicsThe transcriptome of central nervous system myelin
Rapid nerve conduction in the CNS is facilitated by the insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics is not well understood. Hypo...
ORGANISM(S): Mus musculus 
2016-06-24 | GSE78151 | GEO
TranscriptomicsThe transcriptome of central nervous system myelin
Rapid nerve conduction in the CNS is facilitated by the insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics is not well understood. Hypo...
ORGANISM(S): Mus musculus 
2016-12-31 | GSE76458 | GEO
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