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UnknownIL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability.
Not available
S-EPMC2758590 | biostudies-literature
TranscriptomicsIL-3 coordination of myeloblast function by modulating mRNA stability
The growth factor interleukin-3 (IL-3) promotes the survival and growth of multipotent hematopoietic progenitors and stimulates myelopoiesis. It has also been reported to oppose terminal granulopoiesis and to support leukemic cell growth through autocrine or paracrine mechanisms. We used kinetic mic...
ORGANISM(S): Mus musculus 
2009-06-01 | GSE12067 | GEO
TranscriptomicsmiRNA expression in granulopoiesis
Normal human neutrophil development is a complex biological process, where the balance between cell proliferation, differentiation and apoptosis is tightly regulated by a transcriptional program that results in the production of appropriate numbers of circulating mature neutrophils. MicroRNAs (miRNA...
ORGANISM(S): Homo sapiens 
2010-04-22 | E-GEOD-21437 | biostudies-arrayexpress
TranscriptomicsIL-3 coordination of myeloblast function by modulating mRNA stability
The growth factor interleukin-3 (IL-3) promotes the survival and growth of multipotent hematopoietic progenitors and stimulates myelopoiesis. It has also been reported to oppose terminal granulopoiesis and to support leukemic cell growth through autocrine or paracrine mechanisms. We used kinetic m...
ORGANISM(S): Mus musculus 
2009-06-01 | E-GEOD-12067 | biostudies-arrayexpress
GenomicsMus musculus
IL-3 coordination of myeloblast function by modulating mRNA stability
PRJNA113315 | ENA
TranscriptomicsGene expression profile at single-cell level of hematopoietic stem and progenitor cells (HSPCs) from individuals with chronic myelomonocytic leukemia (CMML)
Myeloblast expansion is a hallmark of disease progression in leukemias and comprises of CD34+ hematopoeitic stem and progeneitor cells. We used single-cell RNA sequencing (scRNAseq) to analyze the transcriptional states of HSPCs in CMML.
ORGANISM(S): Homo sapiens 
2022-11-04 | GSE211033 | GEO
UnknownIdentification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition.
Not available
S-EPMC4615388 | biostudies-literature
TranscriptomicsIdentification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition [miRNA]
Treatment of leukemia cells with 1,25-dihydroxyvitamin D3 may overcome their differentiation block and lead to the transition from myeloblasts to monocytes. To identify microRNA-mRNA networks relevant for myeloid differentiation, we profiled the expression of mRNAs and microRNAs associated to the lo...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-67837 | biostudies-arrayexpress
TranscriptomicsIdentification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition [mRNA]
Treatment of leukemia cells with 1,25-dihydroxyvitamin D3 may overcome their differentiation block and lead to the transition from myeloblasts to monocytes. To identify microRNA-mRNA networks relevant for myeloid differentiation, we profiled the expression of mRNAs and microRNAs associated to the lo...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-67826 | biostudies-arrayexpress
UnknownCSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells.
Not available
S-EPMC8582394 | biostudies-literature
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