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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
TranscriptomicsMusashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to r...
ORGANISM(S): Homo sapiens 
2010-07-11 | E-GEOD-16432 | biostudies-arrayexpress
MetabolomicsTranscobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism

BACKGROUND: SLE is a complex autoimmune disease with deleterious effects on various organs. Accumulating evidence has shown abnormal vitamin B12 and one-carbon flux contribute to immune dysfunction. Transcobalamin II (TCN2) belongs to the vitamin B12-binding protein family respon...

2024-05-28 | MTBLS9136 | MetaboLights
TranscriptomicsAutotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation
Autotaxin (ATX) has been reported to act as a motility and growth factor in a variety of cancer cells. The ATX protein acts as a secreted lysophospholipase D (lysoPLD) by converting lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which signals via G-protein coupled receptors and has im...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-MTAB-1169 | biostudies-arrayexpress
TranscriptomicsIntegrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia
Background: MicroRNAs are regulators of gene expression, mainly functioning by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been shown for acute myeloid leukemia, a disease also characterized by altered gene expression associated with distinct genomic aberrat...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31644 | biostudies-arrayexpress
TranscriptomicsA novel tumor-associated myeloid cell population inhibits antigen-specific immune responses in cancer patients
Tumor progression is associated with an immunosuppressive microenvironment that consists of several elements, such as regulatory T cells, type 2 macrophages and myeloid-derived suppressor cells. Here, we identify for the first time a BDCA1+CD14+ population of immunosuppressive cells that resides bot...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-75042 | biostudies-arrayexpress
ProteomicsSynergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 and KIT. FLT3 and KIT mutations are associated with poor...
ORGANISM(S): Mus Musculus 
2023-01-26 | PXD030214 | panorama
TranscriptomicsTranscriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils
The role of myeloid cells in supporting cancer growth is well established. Most work has focused on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, but tumor-associated neutrophils (TAN) are also known to be capable of augmenting tumor growth. However, little is kno...
ORGANISM(S): Mus musculus 
2013-01-04 | E-GEOD-43254 | biostudies-arrayexpress
TranscriptomicsDynamic transcriptomes of human myeloid leukemia cells
To identify the mechanisms controlling chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) in humans, we analyzed genome-wide transcription dynamics in three myeloid leukemia cell lines (K562, HL-60, and THP1) using high-throughput sequencing technology. Using KEGG analysis, we found tha...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-46164 | biostudies-arrayexpress
ProteomicsImmunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata
We have demonstrated therapeutic efficacy of MDSC in mouse Alopecia Areata (AA). In the same AA model, we now asked whether MDSC exosomes (MDSC-Exo) can replace MDSC. MDSC-Exo from bone marrow cells (BMC) cultures of healthy donors could substantially facilitate treatment. With knowledge on MDSC-Exo...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-08-16 | MSV000082825 | MassIVE
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