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MetabolomicsBMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. We discovered that BMAL1 is a ferroptosis suppressor. Furthermore, it was also found to be overexpressed in AML patients, affecting the cell cycle and promoting tumor cell growth and progression. In this study, we furthe...
2025-01-24 | MTBLS11557 | MetaboLights
TranscriptomicsCDKN1B encoding the cyclin-dependent kinase inhibitor 1B (p27) is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia
Alterations of the short arm of chromosome 12 (12p) occur in various hematological malignancies and ETV6 and CDKN1B, which are located on 12p, have been implicated as leukemogenic genes of interest. Design and Methods: We selected 7 patients with myeloid malignancies and small 12p deletions by FISH ...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-27832 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of patients with various myeloid malignancies including differential levels of 5-hydroxymethylcytosine
TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid...
ORGANISM(S): Homo sapiens 
2010-12-11 | E-GEOD-25706 | biostudies-arrayexpress
TranscriptomicsRECURRENT SETBP1 MUTATIONS IN ATYPICAL CHRONIC MYELOID LEUKEMIA
RNA-Seq analysis of atypical chronic myeloid leukemia samples We sequenced leukemic mRNA from 13 Atypical Cronic Mieloid Leukemia (aCML) samples by Illumina GAIIx. Transcriptomic profiles, differentially expressed genes and pathway enrichment analysis were obtained comparing 7 SETBP1-mutated sample...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42146 | biostudies-arrayexpress
GenomicsChromosome 11 analysis in myeloid malignancies - WES
Chromosome 11 analysis in myeloid malignancies - WES
PRJEB4555 | ENA
TranscriptomicsChromosome 11 analysis in myeloid malignancies - microarrays
blood samples from patients with myeloid malignancies were analyzed using Affymetrix Genome-Wide Human SNP 6.0 arrays.
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MTAB-1845 | biostudies-arrayexpress
GenomicsAcquired somatic variants in inherited myeloid malignancies
Acquired somatic variants in inherited myeloid malignancies
PRJEB49554 | ENA
GenomicsChromosome 11 analysis in myeloid malignancies - WES
Blood samples from patients with myeloid malignancies were analyzed using whole exome sequencing (WES). Data set from genotyping by microarray of the same samples has been deposited in ArrayExpress under accession number E-MTAB-1845 (https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1845/).
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MTAB-1850 | biostudies-arrayexpress
GenomicsGlobal methylation alterations in Dnmt3aKO derived malignancies
To test the long-term effects of lack of Dnmt3a on mouse HSCs, we established a cohort of lethally irradiated mice transplanted with Dnmt3a-KO or WT HSC control cells. Dnmt3a deletion in purified HSCs transplanted alone leads to an array of hematologic disorders that models the spectrum of disorders...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-60264 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of erythroid and megakaryocytic acute myeloid leukemia patient cells
Single-cell RNA sequencing was performed on bone marrow mononuclear of a patient with acute myeloid leukemia with erythroid differentiation of the blasts and on peripheral blood mononuclear cells of a patient with acute myeloid leukemia with megakaryocytic differentiation of the blasts. Raw data for...
ORGANISM(S): Homo sapiens 
2022-12-05 | E-MTAB-12607 | biostudies-arrayexpress
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