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TranscriptomicsTransposon-based construction of strand-specific RNA-seq libraries
We have developed two methods for efficiently consructing RNA-seq libraries using transposition. Each method constructs high quality RNA-seq libraries when compared to standard approaches. One of the methods (Directional Tn-RNA-seq) maintains strand-of-origin information and exhibits strand specifi...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-32307 | biostudies-arrayexpress
GenomicsAnalysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation
To assess variation and inheritance of genome-wide patterns of DNA methylation simultaneously in humans, we applied reduced representation bisulfite sequencing (RRBS) to somatic DNA from six members of a three-generation family. Reduced representation bisulfite sequencing was applied to genomic DNA ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-30253 | biostudies-arrayexpress
TranscriptomicsGenistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of binding sites in a cell type-specific manner
To obtain an integrated view of gene regulation in response to environmental and endogenous estrogens on a genome-wide scale, we performed ChIP-seq, to identify estrogen receptor 1 (ER) binding sites, and RNA-seq in endometrial cancer cells exposed to bisphenol A (BPA; found in plastics), genistein ...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-38234 | biostudies-arrayexpress
TranscriptomicsBreast Cancer RNA-seq
RNA-seq was performed on breast cancer cell lines and primary tumors RNA-seq was performed on 28 breast cancer cell lines, 42 Triple Negative Breast Cancer (TNBC) primary tumors, and 42 Estrogen Receptor Positive (ER+) and HER2 Negative Breast Cancer primary tumors, 30 uninovlved breast tissue sampl...
ORGANISM(S): Homo sapiens 
2014-06-11 | E-GEOD-58135 | biostudies-arrayexpress
GenomicsDNA Methylation by Reduced Representation Bisulfite Seq from ENCODE/HudsonAlpha
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Florencia Pauli mailto:fpauli@hudsonalpha.org). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). This trac...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-27584 | biostudies-arrayexpress
GenomicsCTCF Binding Sites by ChIP-seq from ENCODE/University of Washington
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Richard Sandstrom mailto:sull@u.washington.edu). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). This tra...
ORGANISM(S): Homo sapiens 
2011-06-29 | E-GEOD-30263 | biostudies-arrayexpress
TranscriptomicsSpike-in Experiment for ChIP-chip Simulation
The most widely-used method for detecting genome-wide protein-DNA interactions is chromatin immunoprecipitation on tiling microarrays, commonly known as ChIP-chip. Here, we conducted the first objective analysis of tiling array platforms and analysis algorithms in a simulated ChIP-chip experiment. M...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-9732 | biostudies-arrayexpress
GenomicsHigh-throughput sequencing of ES cell lines, ES-derived cells, and fetal and normal livers
Publication title: Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver To investigate the role of DNA methylation during human development, we developed Methyl-seq, a method that assays DNA methylation at more than 90,000 regions...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-29071 | biostudies-arrayexpress
TranscriptomicsSystematic evaluation of variability in simulated ChIP-chip experiments
The most widely-used method for detecting and measuring genome-wide protein-DNA interactions is chromatin immunoprecipitation on tiling microarrays, commonly known as ChIP-chip. Many tiling array platforms, amplification methods, and analysis algorithms exist for ChIP-chip, but a rigorous assessment...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-9842 | biostudies-arrayexpress
UnknownThe TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.
Not available
S-EPMC5112176 | biostudies-literature
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