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TranscriptomicsNovel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis
Skeletal muscle contains long multinucleated and contractile structures known as muscle fibers, which arise from the fusion of myoblasts into nucleated myotubes during myogenesis. The myogenic regulatory factor (MRF) MYF5 is the earliest to be expressed during myogenesis and functions as a transcri...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-73704 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 2C5/7 myoD-/-;myf5-/- fibroblast cells expressing MyoD, Myf5, myogenin, or hrGFP
Gene expression changes induced by MyoD or Myf5 were examined in a double-knockout fibroblast cell line lacking endogenous functional myoD or myf5 genes. Use of this cell line precluded the possibility of auto- or cross-activation of endogenous myoD or myf5. Myogenin or hrGFP were expressed in paral...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3245 | biostudies-arrayexpress
GenomicsDistinct activities of Myf5 and MyoD indicate sequential roles in skeletal muscle lineage specification and differentiation (ChIP-Seq)
In this work we compare the molecular functions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle specification and differentiation. We find MyoD and Myf5 bind the same sites genome-wide but have distinct functions: Myf5 induces histone acetylation without...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-75370 | biostudies-arrayexpress
TranscriptomicsDistinct activities of Myf5 and MyoD indicate sequential roles in skeletal muscle lineage specification and differentiation (RNA-Seq)
In this work we compare the molecular functions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle specification and differentiation. We find MyoD and Myf5 bind the same sites genome-wide but have distinct functions: Myf5 induces histone acetylation without...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-75631 | biostudies-arrayexpress
GenomicsTranscriptome profiling of muscle stem cell subpopulations based on differential expression of Myf5
Transcriptome profiling of muscle stem cell subpopulations based on differential expression of Myf5
PRJNA854801 | ENA
TranscriptomicsGene expression profiling of Myf5-Cre;Smad4flox/flox mouse models of tongue development
We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue morphogenesis by comparing the transcriptomes of tongue derived from Myf5-Cre;Smad4flox/flox mutant and Myf5-Cre;Smad4flox/+ control mice at day E13.5. Based on gene ex...
ORGANISM(S): Mus musculus 
2012-02-03 | E-GEOD-35357 | biostudies-arrayexpress
TranscriptomicsMyoD, Myf5, myogenin, or hrGFP expressed in 2C5/7 myoD-/-;myf5-/- fibroblast cells
Gene expression changes induced by MyoD or Myf5 were examined in a double-knockout fibroblast cell line lacking endogenous functional myoD or myf5 genes. Use of this cell line precluded the possibility of auto- or cross-activation of endogenous myoD or myf5. Myogenin or hrGFP were expressed in paral...
ORGANISM(S): Mus musculus 
2005-09-07 | GSE3245 | GEO
GenomicsLoss of FSTL1 in the Myf5 lineage causes brown adipose tissue atrophy
Loss of FSTL1 in the Myf5 lineage causes brown adipose tissue atrophy
PRJNA626348 | ENA
UnknownPTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.
Not available
S-EPMC3488151 | biostudies-literature
UnknownMultiple upstream modules regulate zebrafish myf5 expression.
Not available
S-EPMC1769357 | biostudies-literature
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