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ProteomicsMyh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
Impaired alveolar formation and maintenance are features of many pulmonary diseases that are associated with significant morbidity and mortality. In a forward genetic screen for modulators of mouse lung development, we identified the non-muscle myosin II heavy chain gene, Myh10. Myh10 mutant pups ex...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-19 | PXD011139 | Pride
Myh10/nm iib  ecm remodeling  mmp  thbs  lung development  emphysema 
TranscriptomicsIGR_Raslova_LMMC
Characterization of genetic alterations in monocoyte lineage (CD14+ cells) of two CMML (Chronicle Myelo-Monocytic Leukemia) patients. Previously we have shown that RUNX1 downregulates MYH10 expression in megacaryocyte lineage leading in MYH10 overexpression in platelets of patients wiht RUNX1 geneti...
ORGANISM(S): Homo sapiens 
2013-01-16 | E-MTAB-1121 | biostudies-arrayexpress
UnknownMyh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.
Not available
S-EPMC6214918 | biostudies-literature
UnknownMYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM).
Not available
S-EPMC10575922 | biostudies-literature
UnknownDown-regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway.
Not available
S-EPMC8650048 | biostudies-literature
UnknownNon-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis.
Not available
S-EPMC10283425 | biostudies-literature
UnknownMYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.
Not available
S-EPMC10190571 | biostudies-literature
UnknownA human de novo mutation in MYH10 phenocopies the loss of function mutation in mice.
Not available
S-EPMC3927488 | biostudies-literature
UnknownHeterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling.
Not available
S-EPMC10765599 | biostudies-literature
UnknownMutations in CFAP57 disrupt the localization of MYH10 and IFT88, leading to flagellogenesis failure in humans and mice.
Not available
S-EPMC12751231 | biostudies-literature
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