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ProteomicsMyh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
Impaired alveolar formation and maintenance are features of many pulmonary diseases that are associated with significant morbidity and mortality. In a forward genetic screen for modulators of mouse lung development, we identified the non-muscle myosin II heavy chain gene, Myh10. Myh10 mutant pups ex...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-19 | PXD011139 | Pride
Myh10/nm iib  ecm remodeling  mmp  thbs  lung development  emphysema 
UnknownA human de novo mutation in MYH10 phenocopies the loss of function mutation in mice.
Not available
S-EPMC3927488 | biostudies-literature
TranscriptomicsGenome-wide RNA analysis of the effects of MASTL silencing in breast cancer cells
The effect of short term (24h and 48h) silencing of MASTL for total transcriptome was studied in human breast cancer cell line (MDA-MB-231). Microtubule-associated serine/threonine-protein kinase-like (MASTL) is a mitosis-accelerating kinase with emerging roles in cancer progression. However, possib...
ORGANISM(S): Homo sapiens 
2020-04-14 | GSE131833 | GEO
UnknownMASTL promotes cell contractility and motility through kinase-independent signaling.
Not available
S-EPMC7265322 | biostudies-literature
GenomicsGenome-wide RNA analysis of the effects of MASTL silencing in breast cancer cells
Genome-wide RNA analysis of the effects of MASTL silencing in breast cancer cells
PRJNA545096 | ENA
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