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ProteomicsMavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation
Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin that drives contraction. Therapeutic intervention for hypertrophic cardiomyopathy has until recentl...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-03-26 | PXD059316 | Pride
Dsbu Skyline Cardiac myosin Quantitative crosslinking ms 
ProteomicsDysregulated Skeletal Muscle Myosin Super-relaxation in Type II, but Not Type I, Diabetes Mellitus
Skeletal muscle plays a critical role in the onset and development of type II diabetes. However, very few studies have investigated the potential pathogenic role of its most abundant protein, myosin. Hence, here, we aim to define this by focusing on myosin energy-saving state known as super-relaxed ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053022 | Pride
Proteomics Single muscle fiber Skeletal muscle Diabetes 
UnknownMathematical modeling of Myosin induced bistability of Lamellipodial fragments.
Not available
S-EPMC5206284 | biostudies-literature
UnknownMechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA.
Not available
S-EPMC3025356 | biostudies-literature
GenomicsNuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation
Nuclear myosin 1c (NM1) is emerging as regulator of transcription and chromatin organization. Using a genome-wide approach we report here that NM1 binds across the mammalian genome with occupancy peaks at class II gene promoters, correlating with distributions of RNA Polymerase II (Pol II) and activ...
ORGANISM(S): Mus musculus 
2015-05-04 | E-GEOD-66542 | biostudies-arrayexpress
UnknownMicroscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C.
Not available
S-EPMC8733265 | biostudies-literature
UnknownA role for myosin 1e in cortical granule exocytosis in Xenopus oocytes.
Not available
S-EPMC2820112 | biostudies-literature
UnknownDouble-headed binding of myosin II to F-actin shows the effect of strain on head structure.
Not available
S-EPMC10544818 | biostudies-literature
UnknownProbing actin-activated ATP turnover kinetics of human cardiac myosin II by single molecule fluorescence.
Not available
S-EPMC11615843 | biostudies-literature
UnknownMyosin V exhibits a high duty cycle and large unitary displacement.
Not available
S-EPMC2198872 | biostudies-literature
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