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TranscriptomicsTranscriptional profiling of human myxoid liposarcoma xenografts treated with trabectedin
To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes we have developed and characterized two MRCL xenografts differing for the breakpoint of the fusion gene FUS- HOP, respectively of type II...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-MTAB-1809 | biostudies-arrayexpress
TranscriptomicsThe Chimeric Oncoprotein TLS-CHOP Represses Expression of the Anticancer Cytokine MDA-7/IL-24 in Myxoid Liposarcoma Cells
The TLS-CHOP fusion protein is found in the majority of human myxoid liposarcomas (MLS), and is thought to have oncogenic functions. Until now, however, the molecular function of TLS-CHOP for oncogenesis is still elusive. In this report, we have revealed that knockdown of TLS-CHOP by specific siRN...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-33616 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of myxoid liposarcomas (validation set INT-B)
FUS-CHOP and EWS-CHOP balanced translocations characterize myxoid liposarcoma which encompasses myxoid (ML) and round cell (RC) variants initially believed to be distinct diseases. Currently, myxoid and RC liposarcoma are regarded to represent the well differentiated and the poorly differentiated en...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-55465 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of myxoid liposarcomas (training set INT-A)
FUS-CHOP and EWS-CHOP balanced translocations characterize myxoid liposarcoma which encompasses myxoid (ML) and round cell (RC) variants initially believed to be distinct diseases. Currently, myxoid and RC liposarcoma are regarded to represent the well differentiated and the poorly differentiated en...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-55464 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of patient-derived xenograft models of myxoid liposarcoma either responsive or resistant to trabectedin treatment.
Transcriptional profiling of patient-derived xenograft models of myxoid liposarcoma with either FUS-CHOP type I, named as ML017, or FUS-CHOP type III, named as ML006. Both ML017 and ML006 are responsive to trabectedin treatment, while model ML017/ET has aquired resistance to the drug. Samples are ei...
ORGANISM(S): Homo sapiens 
2020-01-10 | E-MTAB-8632 | biostudies-arrayexpress
TranscriptomicsWhole genome microarray analysis in myxoid liposarcoma
In order to identify new key molecules in the pathogenesis of myxoid liposarcoma, we performed comparative gene expression profiling in myxoid liposarcoma and fat tissue samples. Whole genome microarray analysis was performed on eight primary myxoid liposarcoma samples and an RNA pool of eight healt...
ORGANISM(S): Homo sapiens 
2014-10-28 | E-GEOD-62747 | biostudies-arrayexpress
ProteomicsCharacterisation of a cell-free myxoid liposarcoma patient-derived xenograft scaffold model
Myxoid liposarcoma (MLS) is the second most common type of liposarcoma, and today few model systems to study the disease exists. To be able to model the disease in vitro, cell-free scaffolds from MLS patient-derived xenograft (PDX) models were generated. The MLS scaffolds were then used as a 3D grow...
ORGANISM(S): Homo sapiens (Human) 
2024-05-08 | PXD023792 | Pride
Cancer Human Fus-ddit3 expression and tumor microenvironment 
TranscriptomicsTLS-CHOP Fusion Oncoprotein Regulates MicroRNA-486 in Human Myxoid Liposarcoma
MicroRNAs (miRNAs, miRs) are small noncoding RNAs, which control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumor suppressor genes, play important roles in carcinogenesis. Myxoid liposarcomas (MLS) are characterized by t(12;16)(q13;p11) translocation and expressio...
ORGANISM(S): Mus musculus 
2013-03-23 | E-GEOD-36966 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of myxoid liposarcomas
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-55466 | biostudies-arrayexpress
TranscriptomicsGene expression analysis compared myxoid liposarcoma tissue with normal fat tissue
To identify molecular biomakers that are useful for diagnosis and its targeting treatment, we compared the gene expression profile of myxiod liposarcoma with that of normal fat tissue. In the present study, we studied about gene expression profiles comparing 6 non-preoperative myxoid liposarcoma wit...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-59568 | biostudies-arrayexpress
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