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MetabolomicsN6-methyladenosine modification is not a general trait of positive-sense RNA viral genomes

Despite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these findings are mostly based on m6A-seq, an antibody-dependent technique with...

2024-01-25 | MTBLS6978 | MetaboLights
MetabolomicsN6-methyladenosine–modified circSLTM inhibits gastric cancer cell proliferation and promotes ferroptosis via interaction with HSPA8

Circular RNAs (circRNAs) are dysregulated in cancers, with N6-methyladenosine (m⁶A)-modified species acting as key regulators of ferroptosis via iron metabolism and lipid peroxidation. This study examines the role of circSLTM (circ-0000605) in gastric cancer (GC). Clinical analyses of GEO data an...

2026-01-16 | MTBLS13702 | MetaboLights
GenomicsN6-methyladenosine RNA methylome analyses in podocyte cell lines
N6-methyladenosine RNA methylome analyses in podocyte cell lines
PRJNA1044816 | ENA
TranscriptomicsGenome-wide identification of N6-methyladenosine by microarray
Although internal PolyA RNA modification N6-methyladenosine (m6A) plays essential roles in diverse biological processes, technology to detect precise m6A sites at transcriptome-wide scale is lacking. Here, we discovered that m6A interferes A (Adenine) – U (Uracil) or A-T (Thymidine) pairing. Based o...
ORGANISM(S): Mus musculus 
2015-09-08 | E-GEOD-62530 | biostudies-arrayexpress
GenomicsN6-methyladenosine RNA methylome analyses in human prostate cell lines.
N6-methyladenosine RNA methylome analyses in human prostate cell lines.
PRJNA622480 | ENA
TranscriptomicsN6-methyladenosine Modulates Messenger RNA Translation Efficiency
N6-methyladenosine (m6A) is the most abundant internal messenger (mRNA) modification in mammalian mRNA. This modification is reversible and non-stoichiometric, which potentially adds an additional layer of variety and dynamic control of mRNA metabolism. The m6A-modified mRNA can be selectively recog...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-63591 | biostudies-arrayexpress
TranscriptomicsYTHDF3 improves translation initiation of mRNAs with N6-methyladenosine methylation at 5’ untranslated region by facilitating eIF2AK2 recruitment in oxaliplatin-resistant colorectal cancer - RIP-seq dataset
Oxaliplatin as a first-line drug frequently causes the chemo-resistance on colorectal cancer (CRC). N6-methyladenosine (m6A) methylation has been largely acknowledged in multiple biological functions. However, the molecular mechanisms underlying the m6A methylation in modulating anticancer drug resi...
ORGANISM(S): Homo sapiens 
2022-02-04 | E-MTAB-11321 | biostudies-arrayexpress
TranscriptomicsIdentification and Characterization of the Mammalian Nuclear RNA N6-Adenosine Methyltransferase Core Complex
N6-methyladenosine (m6A) is the most prevalent internal modification found in mammalian messenger and non-coding RNAs. The discoveries of functionally significant demethylases that reverse this methylation as well as the recently revealed m6A distributions in mammalian transcriptomes strongly indica...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-46705 | biostudies-arrayexpress
GenomicsThe role of N6-Methyladenosine (m6A) methylation in pathological myopia
The role of N6-Methyladenosine (m6A) methylation in pathological myopia
PRJNA864810 | ENA
GenomicsN6-methyladenosine RNA methylome analyses in cyclophosphamide-treated neonatal rat cardiac myocytes.
N6-methyladenosine RNA methylome analyses in cyclophosphamide-treated neonatal rat cardiac myocytes.
PRJNA763909 | ENA
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