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TranscriptomicsHigh salt primes a specific activation state of macrophages, M(Na)
Purpose: Investigate effects of high salt on human macrophage activation Methods: Human monocytes-derived macrophages were treated by additional 51mM NaCl for 24 hours (NaCl groups) or not (Control groups). mRNA profiles were generated by RNA-Seq, in triplicate, using Ion proton（Life tech). qRT–PCR ...
ORGANISM(S): Homo sapiens 
2015-09-23 | E-GEOD-68482 | biostudies-arrayexpress
TranscriptomicsLocalized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions
mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-IN...
ORGANISM(S): Canis lupus familiaris 
2010-05-18 | E-GEOD-13253 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in Peripheral Blood in Untreated New Onset Systemic Juvenile Idiopathic Arthritis
Systemic Juvenile Idiopathic Arthritis (sJIA) has been strongly associated with macrophage activation syndrome (MAS). To better understand the pathogenesid of sJIA and to facilitate the search for MAS biomarkers, we examine gene expression profiles in untreated new onset sJIA. 17 new onset sJIA pat...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-7753 | biostudies-arrayexpress
ProteomicsPhysiological responses and proteomic analysis of different barley varieties under alkaline stress
Soil salinization threatens agricultural development, and understanding the alkali tolerance mechanism of barley is crucial for breeding. Using the alkali-tolerant barley variety Jia-HY460-6R and the alkali-sensitive variety Noire Maroc as materials, morphological and physiological indicators were d...
ORGANISM(S): Hordeum Vulgare 
2025-11-10 | PXD070668 |
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
UnknownInhibition of Na+/K+ ATPase blocks Zika virus infection in mice.
Not available
S-EPMC7363852 | biostudies-literature
UnknownBAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells
Not available
S-JCBD-201701064 | bioimages
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
UnknownHigh salt primes a specific activation state of macrophages, M(Na).
Not available
S-EPMC4528058 | biostudies-literature
UnknownGamma-aminobutyric acid (GABA) alleviates salt damage in tomato by modulating Na+ uptake, the GAD gene, amino acid synthesis and reactive oxygen species metabolism.
Not available
S-EPMC7547442 | biostudies-literature
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