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TranscriptomicsChromatin signature identifies monoallelic gene expression across mammalian cell types (RNA-seq)
Monoallelic expression of autosomal genes (MAE) is a widespread epigenetic phenomenon which is poorly understood, due in part to current limitations of genome-wide approaches for assessing it. Recently, we reported that a specific histone modification signature is strongly associated with MAE, and d...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67379 | biostudies-arrayexpress
GenomicsChromatin signature identifies monoallelic gene expression across mammalian cell types (ChIP-seq)
Monoallelic expression of autosomal genes (MAE) is a widespread epigenetic phenomenon which is poorly understood, due in part to current limitations of genome-wide approaches for assessing it. Recently, we reported that a specific histone modification signature is strongly associated with MAE, and d...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67380 | biostudies-arrayexpress
TranscriptomicsWhole RNA-seq on clones of GM12878 lymphoblastoid clones DF1 and DF2
Analysis of Allelic bias in clonal lymphoblastoid cells. Abstract: In mammals, numerous autosomal genes are subject to mitotically stable monoallelic expression (MAE), including genes that play critical roles in a variety of human diseases. Due to challenges posed by the clonal nature of MAE, very l...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-52090 | biostudies-arrayexpress
TranscriptomicsAnalysis of Allelic bias in gDNA, cDNA and ChIP with H3K27me3 and H3K36me3 antibody with multiplexed padlock probe approach
In this experiment, we asked how the allelic distribution of the active and repressive chromatin marks in clonal cell lines relates to the transcriptional allelic bias. A multiplexed padlock probe approach (Zhang et al., 2009) enabled us to assess allelic bias in heterozygous exonic SNPs in two clo...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-53628 | biostudies-arrayexpress
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