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ProteomicsExpression of Siglec-E alters the proteome of LPS-activated macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis Expression of Siglec-E alters the proteome of LPS-activated macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis
Siglec-E is a murine CD33-related siglec that functions as an inhibitory receptor and is expressed mainly on neutrophils and macrophage populations. Recent studies have suggested that siglec-E is an important negative regulator of LPS-TLR4 signalling and one report (Wu et al 2016) claimed that sigl...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-09 | PXD008406 | Pride
Mouse bmdm lc-msms 
ProteomicsTowards understandingTissue Mϕ heterogeneity and functions using quantitative proteomics
Resident macrophages are important for maintaining tissue homeostasis and for defence against infections, but their precise functions in different tissues are not fully elucidated.We have used high resolution quantitative proteomics to investigate the functions of splenic red pulp macrophages and pe...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-24 | PXD019362 | Pride
Tissue Mouse Macrophages Lcmsms 
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