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UnknownPEA15 regulates the DNA damage induced cell cycle checkpoint and oncogene-directed transformation
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ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-39297 | biostudies-other
TranscriptomicsOncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells
Oncogene-induced DNA methylation-mediated transcriptional silencing of tumor suppressors frequently occurs in cancer, but the mechanism and functional role of this silencing in oncogenesis is not fully understood. Here, we show that oncogenic epidermal growth factor receptor (EGFR) induces silencing...
ORGANISM(S): Homo sapiens 
2016-06-23 | E-GEOD-39292 | biostudies-arrayexpress
TranscriptomicsPEA15 regulates the DNA damage induced cell cycle checkpoint and oncogene-directed transformation
Regulation of the DNA damage response and cell cycle progression is critical for maintaining genome integrity. Here we report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase-dependent manner. PEA15 expression oscillates throughout the cell cycle, and the l...
ORGANISM(S): Homo sapiens 
2014-04-07 | E-GEOD-39297 | biostudies-arrayexpress
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