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MetabolomicsMetabolomic correlation-network modules in Arabidopsis based on a graph-clustering approach
Deciphering the metabolome is essential for a better understanding of the cellular metabolism as a system. Typical metabolomics data show a few but significant correlations among metabolite levels when data sampling is repeated across individuals grown under strictly controlled conditions. Although ...
2014-03-01 | MTBLS45 | MetaboLights
MetabolomicsUnbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana
Metabolites are not only the catalytic products of enzymatic reactions but also the active regulators or the ultimate phenotype of metabolic homeostasis in highly complex cellular processes. The modes of regulation at the metabolome level can be revealed by metabolic networks. We investigated the me...
2014-03-01 | MTBLS40 | MetaboLights
TranscriptomicsA Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia
The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clin...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MEXP-3916 | biostudies-arrayexpress
TranscriptomicsChanges in mRNA Stability Associated with Cold Stress in Arabidopsis Cells
Control of mRNA half-life is a powerful strategy to adjust individual mRNA levels to various stress conditions, because the mRNA degradation rate controls not only the steady-state mRNA level but also the transition speed of mRNA levels. Here, we analyzed mRNA half-life changes in response to cold s...
ORGANISM(S): Arabidopsis thaliana 
2012-12-16 | E-GEOD-31837 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of strain EG4 vs. Nipponbare
In the japonica rice strain Gimbozu EG4, the DNA transposon mPing is actively transposing to attain over 1,000 copies, whereas in Nipponbare, where this element is virtually silent and has only 50 copies. To analyze the impact of such a massive amplification of transposable element on gene regulatio...
ORGANISM(S): Oryza sativa Japonica Group 
2010-06-20 | E-GEOD-15021 | biostudies-arrayexpress
UnknownPhotoreaction pathways and photointermediates of retinal-binding photoreceptor proteins as revealed by in situ photoirradiation solid-state NMR spectroscopy.
Not available
S-EPMC6441423 | biostudies-literature
UnknownRelationship between adherence to bictegravir/emtricitabine/tenofovir alafenamide fumarate and clinical outcomes in people with HIV in Japan: a claims database analysis.
Not available
S-EPMC11263482 | biostudies-literature
TranscriptomicsCharacterization of an Oxaliplatin Sensitivity Predictor in a preclinical Murine Model of Colorectal Cancer
Despite advances in contemporary chemotherapeutic strategies, long term survival still remains elusive for patients with metastatic colorectal cancer. A better understanding of the molecular markers of drug sensitivity to match therapy with patient is needed to improve clinical outcomes. In this stu...
ORGANISM(S): Homo sapiens 
2012-02-17 | E-GEOD-28691 | biostudies-arrayexpress
TranscriptomicsThe NOD/SCID Xenograft Model Provides Clinically-Relevant Insights into Glucocorticoid-Induced Gene Expression in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia
Introduction. Glucocorticoids are critical drugs used to treat acute lymphoblastic leukemia, and response to glucocorticoids is highly predictive of outcome. Here we report a study evaluating the NOD/SCID xenograft mouse model to investigate glucocorticoid-induced gene expression. Methods. NOD/SCID ...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30392 | biostudies-arrayexpress
UnknownDecreased number of inpatients with community-acquired pneumonia during the COVID-19 pandemic: A large multicenter study in Japan.
Not available
S-EPMC8776425 | biostudies-literature
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