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TranscriptomicsExpression data from post mortem Alzheimer's disease brains
To identify molecular pathological alterations in AD brains, we performed interspecies comparative microarray analyses using RNAs prepared from postmortem human brain tissues donated for the Hisayama study and hippocampal RNAs from the triple-transgenic mouse model of AD (3xTg-AD) Three-way ANOVA of...
ORGANISM(S): Homo sapiens 
2013-04-17 | E-GEOD-36980 | biostudies-arrayexpress
Unknown2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway.
Not available
S-EPMC5529524 | biostudies-literature
TranscriptomicsExpression data from Alzheimer's disease model mouse
To identify molecular pathological alterations in AD brains, we performed interspecies comparative microarray analyses using RNAs prepared from postmortem human brain tissues donated for the Hisayama study and hippocampal RNAs from the triple-transgenic mouse model of AD (3xTg-AD) Three-way ANOVA of...
ORGANISM(S): Mus musculus 
2013-04-17 | E-GEOD-36981 | biostudies-arrayexpress
TranscriptomicsExpression data from primary cultured microglia from Fosb-null mouse
To identify genes whose expression is regulated by Fosb gene products in microglia, we performed microarray analysis using RNA prepared from wild-type and fosB-null microglial cells. Microarray analysis revealed that expression levels of 6 genes are altered in primary cultured microglial cells prepa...
ORGANISM(S): Mus musculus 
2014-04-18 | E-GEOD-40714 | biostudies-arrayexpress
UnknownMTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.
Not available
S-EPMC7988129 | biostudies-literature
TranscriptomicsExpression data from fosb gene modified mouse
To examine fosB regulation of neurogenesis, depression and epilepsy, we compared the gene expression profiles of wild type, fosBd/d and fosB-null mice by microarray analysis. Microarray analysis revealed that genes related to neurogenesis, depression and epilepsy are altered in the hippocampus of fo...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-37056 | biostudies-arrayexpress
UnknownComparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.
Not available
S-EPMC5736730 | biostudies-literature
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