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TranscriptomicsRNA-seq analysis of add-back rescued TALEN-mediated LATS2 knockout HeLa-S3 cells
Chromatin modifying activities for construction of appropriate epigenetic landscapes by polycomb repressive complex 2 (PRC2) play an essential role in development and tumorigenesis. However, the spatiotemporal mechanisms by which PRC2 achieves diverse epigenomes for specific tissue or cellular conte...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-GEOD-66388 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of TALEN-mediated LATS2 knockout HeLa-S3 cells
Chromatin modifying activities for construction of appropriate epigenetic landscapes by polycomb repressive complex 2 (PRC2) play an essential role in development and tumorigenesis. However, the spatiotemporal mechanisms by which PRC2 achieves diverse epigenomes for specific tissue or cellular conte...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-GEOD-63537 | biostudies-arrayexpress
TranscriptomicsPRDM14 promotes active DNA demethylation through the Ten-eleven translocation (TET)–mediated base excision repair pathway in embryonic stem cells
Ten-eleven translocation (TET) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytsosine (5fC), and 5-carboxylcytosine (5caC). 5fC/5caC can be excised and repaired by the base excision repair (BER) pathway, implicating 5mC oxidation in active DNA demethylation. Gen...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-52598 | biostudies-arrayexpress
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