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TranscriptomicsGene expression profiles from osteosarcpma samples
Osteosarcoma patients with development of pulmonary metastasis have still poorer prognosis in spite of aggressive treatment. However, molecular mechanism of metastasis is still unknown. We analysed the expression levels of 54,613 probe sets in surgical 27 samples of osteosarcoma with GeneChip Human...
ORGANISM(S): Homo sapiens 
2010-02-22 | E-GEOD-14827 | biostudies-arrayexpress
TranscriptomicsGene expression profile of poorly differentiated synovial sarcoma
Poorly differentiated type synovial sarcoma (PDSS) is a variant of synovial sarcoma characterized by predominantly round or short-spindled cells. Although accumulating evidence from clinicopathological studies suggests a strong association between this variant of synovial sarcoma and poor prognosis,...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-20196 | biostudies-arrayexpress
TranscriptomicsPseudomonas-derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate
A Pseudomonas aeruginosa-derived neutral ceramidase (PaCDase) isolated from a patient with atopic dermatitis was shown to effectively degrade ceramide in the presence of Staphylococcus aureus-derived lipids or neutral detergents. To understand the effect of ceramide metabolites on the functions of d...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-53670 | biostudies-arrayexpress
TranscriptomicsmiRNA gene expression profiles from osteosarcoma samples and cell lines
Although the introduction of combined neoadjuvant chemotherapy has significantly prolonged the survival, the outcome of OS patients with poor response to chemotherapy is still unfavorable. To develop new therapeutics the elucidation of the entire molecular pathway regulating OS cell proliferation is...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-30934 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity
Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear. GATA3, a master regulator of Th2 cell differentiation...
ORGANISM(S): Mus musculus 
2013-04-19 | E-GEOD-46185 | biostudies-arrayexpress
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