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TranscriptomicsExpression profiling by array in ATLL
Previously, we have shown that an AP-1 family member Fra-2, which is hardly expressed in normal mature T cells, is consistently over-expressed in adult T-cell leukemia/lymphoma (ATLL), and together with JunD, upregulates CCR4 and many other genes including proto-oncogenes c-Myb, MDM2, Bcl-6, and SOX...
ORGANISM(S): Homo sapiens 
2013-05-16 | E-GEOD-38021 | biostudies-arrayexpress
TranscriptomicsBcl6-deficient regulatory T cells
gene expression data from wild-type and Bcl6-/- regulatory T cells in order to find genes regulated by Bcl6 in Treg cells FoxP3+ Tregs were sorted from wild-type (WT) and Bcl6-/- (KO) mice-- 8 samples, 2 from each type of Treg, 2 WT and 2 KO
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-40493 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3
Differentiation of naive CD4 T cells into type 2 helper (Th2) cells is accompanied by chromatin remodeling and increased expression of a set of Th2-specific genes including those encoding Th2 cytokines. IL-4-mediated STAT6 activation induces high levels of transcription of GATA3, a master regulator...
ORGANISM(S): Mus musculus 
2011-03-31 | E-GEOD-28292 | biostudies-arrayexpress
TranscriptomicsThe Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-49968 | biostudies-arrayexpress
TranscriptomicsND and HFD memory phenotype CD4 T cells
We used microarray analysis to identify specific molecular mechanisms controlling Th17 cell differentiation in HFD mice Memory phenotype CD4 T cells derived from ND or HFD mice were selected for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2015-07-02 | E-GEOD-70472 | biostudies-arrayexpress
UnknownA clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy.
Not available
S-EPMC7814014 | biostudies-literature
TranscriptomicsThe polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells.
Following antigen encounter by CD4 T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2 was found to specifically enhance T-helper (Th)1 and Th2 cell differentiation and plasticity. Ezh2 directly bo...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-50729 | biostudies-arrayexpress
TranscriptomicssiRNA profiling human adult T cell leukemia reveals Fra-2 promotes CCR4 expression and cell proliferation
The 4　Fra2-targeting siRNA and 4 control-siRNA samples were used for analysis. Experiment Overall Design: A microarray procedure was performed according to the Affymetrix protocols (Santa Clara, CA). In brief, total RNA extracted from the tumor samples was analyzed with the Agilent 2100 Bioanalyze...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6379 | biostudies-arrayexpress
GenomicsThe polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells [ChIP-seq]
Following antigen encounter by CD4 T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2 was found to specifically enhance T-helper (Th)1 and Th2 cell differentiation and plasticity. Ezh2 directly bo...
ORGANISM(S): Mus musculus 
2013-09-24 | E-GEOD-51079 | biostudies-arrayexpress
UnknownMetabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer's disease (from the Nakayama Study).
Not available
S-EPMC9458733 | biostudies-literature
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