Sort   by:  
 Page size 
GenomicsRedistribution of the Lamin B1 genomic binding profile affects spatial rearrangement of heterochromatic domains and gene expression during senescence
Senescence is a stress responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the spatial redistribution of heterochromatin into senescence-associated heterochromatic foci (SAHFs). Studying a key component of the nuclear lami...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-49341 | biostudies-arrayexpress
ProteomicsNOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence
Senescence, a persistent form of cell cycle arrest, is often associated with a diverse secretome, which provides complex downstream functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence (OIS) is accompanied by a dynamic fluctuation of NOTCH1 a...
ORGANISM(S): Homo sapiens (Human) 
2016-08-03 | PXD004168 | Pride
Plasma membrane profiling Senescence Notch Ras Silac 
TranscriptomicsSpatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Protein synthesis and autophagic degradation are regulated in an opposite manner by mammalian target of rapamycin (mTOR), whereas under certain conditions it would be beneficial if they occured in unison to handle rapid protein turnover. We observed a distinct cellular compartment at the trans-side ...
ORGANISM(S): Homo sapiens 
2011-05-04 | E-GEOD-28464 | biostudies-arrayexpress
GenomicsIndependence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation
This SuperSeries is composed of the following subset Series: GSE38410: Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation (mRNA) GSE38442: Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromati...
ORGANISM(S): Homo sapiens 
2012-07-08 | E-GEOD-38448 | biostudies-arrayexpress
GenomicsIndependence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation (ChIP-Seq)
The expansion of repressive epigenetic marks has been implicated in heterochromatin formation during embryonic development, but the general applicability of this mechanism is unclear. Here we show that nuclear rearrangement of repressive histone marks H3K9me3 and H3K27me3 into non-overlapping struct...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-GEOD-38442 | biostudies-arrayexpress
Sort   by:  
 Page size