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ProteomicsHomologous HipA-like kinases are controlled by internal translational initiation and genetic organisation
HipA-like kinases are widespread bacterial serine-threonine kinases, yet their regulatory mechanisms remain poorly understood. Here, we characterise two novel HipA-like systems, the monocistronic hipL and bicistronic hipIN, containing a HipS-like and a HIRAN domain. We show that hipL contains an int...
ORGANISM(S): Escherichia coli 
2025-12-15 | PXD065186 | Pride
Trna synthetase E. coli Toxin-antitoxin Hipbst Protein kinase Hipba 
ProteomicsDeep phosphoproteomics of Klebsiella pneumoniae reveals HipA-mediated tolerance to ciprofloxacin
Klebsiella pneumoniae belongs to the group of bacterial pathogens causing the majority of antibiotic-resistant nosocomial infections worldwide; however, the molecular mechanisms underlying post-translational regulation of its physiology are poorly understood. Here we perform a comprehensive analysis...
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae Escherichia coli 
2024-11-21 | PXD051521 | Pride
Phosphoproteome  klebsiella pneumoniae  antibiotic tolerance  persistence  mass spectrometry 
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