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UnknownThe KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers.
Not available
S-EPMC3352679 | biostudies-literature
TranscriptomicsHIF-2alpha Knockdown in A498 (VHL-/-) ccRCC cells
HIF-2alpha is essential for (VHL-/-) ccRCC subcutaneous tumor growth in mice, and in tumor cell lines, its inhibition results in increased ROS accumulation, tumor cell death and responsiveness to radiation treatment. We have utilized transcriptional profiling to screen for putative HIF-2alpha target...
ORGANISM(S): Homo sapiens 
2009-08-27 | E-GEOD-16622 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression
Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples for HIF-alpha expression and VHL genotype, in order to define differentially expressed genes Keywords: Patient Sampl...
ORGANISM(S): Homo sapiens 
2008-12-27 | E-GEOD-11904 | biostudies-arrayexpress
TranscriptomicsArray CGH analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression
Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples based on HIF-alpha expression, in order to examine levels of genomic DNA aberration. Keywords: Patient Sample Study ...
ORGANISM(S): Homo sapiens 
2008-12-27 | E-GEOD-13282 | biostudies-arrayexpress
TranscriptomicsHuman BRAF-V600E melanoma cell lines drug sensitive vs drug resistant
aCGH of human melanoma cell lines comparing parental (drug sensitve) vs isogenic drug resistant-derived subline Two condition experiment: two BRAF-V600E mutant cell lines (drug sensitive - parental baseline) vs two derived sublines after chronic exposure to the MEK inhibitor trametinib (drug resista...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-49430 | biostudies-arrayexpress
TranscriptomicsSomatic copy number variation profiling in matched brain and extracranial metastases of melanoma
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between bra...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50495 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of melanoma brain metastases and matched extracranial metastases
An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between bra...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50493 | biostudies-arrayexpress
TranscriptomicsMelanoma brain metastases and matched extracranial metastases
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-50496 | biostudies-arrayexpress
UnknownMastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression.
Not available
S-EPMC8419063 | biostudies-literature
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS)
LIN28 is a conserved RNA binding protein implicated in pluripotency, reprogramming and oncogenesis. Previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, here we elucidate distinct roles of LIN28 regulation via its direct messenger RNA (mRNA) targets. Through cross-linking...
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39872 | biostudies-arrayexpress
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