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ProteomicsWithanolide analogues disrupt a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP (TPP)
Metabolic alterations in cancers precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product inspired small molecules can provide a resource of underexplored chemotypes. We identify W7, a synthetic withanolide analog with pronounced anti-leukemic ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-27 | PXD040692 | Pride
Thermal proteome profiling Expression proteomics Withanolides Natural product-inspired compound libraries 
ProteomicsWithanolide analogues disrupt a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP (Expression proteomics)
Metabolic alterations in cancers precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural product inspired small molecules can provide a resource of underexplored chemotypes. We identify W7, a synthetic withanolide analog with pronounced anti-leukemic ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-27 | PXD040694 | Pride
Thermal proteome profiling Expression proteomics Withanolides Natural product-inspired compound libraries 
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