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MetabolomicsNavigating natural variation in herbivory-induced secondary metabolism in coyote tobacco populations using MS/MS structural analysis
Natural variation can be extremely useful in unraveling the determinants of phenotypic trait evolution but has rarely been analyzed with unbiased metabolic profiling to understand how its effects are organized at the level of biochemical pathways. Native populations of Nicotiana attenuata, a wild to...
2015-06-15 | MTBLS203 | MetaboLights
MetabolomicsChanging environments and genetic variation: natural variation in inbreeding does not compromise short-term physiological responses
Selfing plant lineages are surprisingly widespread and successful in a broad range of environments, despite showing reduced genetic diversity, which is predicted to reduce their long-term evolutionary potential. However, appropriate short-term plastic responses to new environmental conditions might ...
2019-10-25 | MTBLS883 | MetaboLights
MetabolomicsNatural variation of root exudates in Arabidopsis thaliana-linking metabolomic and genomic data
The 19 parent lines of the Arabidopsis thaliana MAGIC collection show significant differences in their root exudate profiles. Changes in metabolism were analyzed by ultra-performance liquid chromatography coupled to electrospray ionization quadrupole time–of–flight mass spectrometry (UPLC-ESI-QTOF-M...
2017-02-03 | MTBLS160 | MetaboLights
MetabolomicsNatural genetic variation in C. elegans identified genomic loci controlling metabolite levels
Not available
ORGANISM(S): Caenorhabditis elegans 
ST000999 | MetabolomicsWorkbench
MetabolomicsThe natural variance of the Arabidopsis floral secondary metabolites
Application of mass spectrometry-based metabolomics enables the detection of genotype-related natural variance in metabolism. Differences in secondary metabolite composition of flowers of 64 Arabidopsis thaliana (Arabidopsis) natural accessions, representing a considerable portion of the natural var...
2018-04-03 | MTBLS528 | MetaboLights
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
MetabolomicsGlycoalkaloid composition explains variation in slug resistance in Solanum dulcamara
In natural environments, plants have to deal with a wide range of different herbivores whose communities vary in time and space. It is believed that the chemical diversity within plant species has mainly arisen from selection pressures exerted by herbivores. So far, the effects of chemical diversity...
2019-06-17 | MTBLS738 | MetaboLights
MetabolomicsComputational workflow to study the seasonal variation of secondary metabolites in nine different bryophytes
In Eco-Metabolomics, non-model organisms are typically studied in their natural environment and relations are made between biochemistry and ecological function. Current challenges when processing such data involve, among others, complex ecological experiment designs, peak detection parameter setting...
2018-06-18 | MTBLS520 | MetaboLights
MetabolomicsSemi‐polar root exudates in natural grassland communities
In the rhizosphere, plants are exposed to a multitude of different biotic and abiotic factors, to which they respond by exuding a wide range of secondary root metabolites. So far, it has been unknown to which degree root exudate composition is species-specific and is affected by land use, the local ...
2018-08-15 | MTBLS671 | MetaboLights
MetabolomicshRUV: Hierarchical approach to removal of unwanted variation for large-scale metabolomics data
Liquid chromatography-mass spectrometry-based metabolomics studies are increasingly applied to large population cohorts, which run for several weeks or even years in data acquisition. This inevitably introduces unwanted intra- and inter-batch variations over time that can overshadow true biological ...
2021-07-05 | MTBLS2483 | MetaboLights
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