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TranscriptomicsFLT3 activation cooperates with MLL-AF4 fusion gene to abrogate the hematopoietic specification of human ESCs
MLL-AF4 is a hallmark genomic aberration which arises prenatally in high-risk infant acute lymphoblastic leukemia (ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hemato-endothelial specification but was not sufficient for transformation. Additional cooperating genetic insults seem requi...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-40103 | biostudies-arrayexpress
UnknownGlobal anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study.

Introduction

Restoration of surgical capacity is essential to post-COVID-19 recovery. This study explored the use and safety of anaesthesia options for inguinal hernia surgery, a common tracer condition, to describe current global practice and highlight opportunities to build the capacity of...
S-EPMC12519944 | biostudies-literature
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