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UnknownNavitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis.
Not available
S-EPMC7377880 | biostudies-literature
ProteomicsApoptotic priming in senescence predicts selective senolysis by quantitative analysis of mitochondrial dependencies
Cellular senescence contributes to a variety of pathologies associated with aging and is implicated as a cellular state in which cancer cells can survive treatment. Reported senolytic drug treatments act through varying molecular mechanisms, but heterogeneous efficacy across the diverse contexts of ...
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD054626 | Pride
Cellular senescence Navitoclax (abt263) 
ProteomicsEffect of senolytics (Navitoclax, ABT263) on recovery following Myocardial Infarction
Ischemia reperfusion injury (IRI) following intervention for myocardial infarction remains an unmet clinical problem. Using an established mouse model, we demonstrated that IRI induces multiple cardiac cell linages to senescence. Senescence is is detrimental to recovery, as treatment with the senoly...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-29 | MSV000085040 | MassIVE
UnknownUsing proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
Not available
S-EPMC7181703 | biostudies-literature
TranscriptomicsCellular senescence in malignant cells promotes tumorigenesis in mouse and patient glioblastoma [bulk RNA-seq]
GBM mouse model: The goal of this study is to compare the transcriptomic landscape at the endpoint of GBMs upon senescent cells deletion. We introduced the p16-3MR transgene in the GBM mouse model to selectively delete senescent cells expressing high level of p16Ink4a (p16Ink4a Hi) upon ganciclovir ...
ORGANISM(S): Mus musculus 
2022-12-15 | GSE168037 | GEO
TranscriptomicsSenescence defines a distinct subset of myofibroblasts that orchestrates immunosuppression in pancreatic cancer
Therapeutic resistance in PDAC is largely attributed to a unique tumor microenvironment embedded with an abundance of cancer associated fibroblasts (CAFs). Distinct CAF populations were recently identified, but the phenotypic drivers and specific impact of CAF heterogeneity remain unclear. In this s...
ORGANISM(S): Homo sapiens 
2024-06-21 | GSE255978 | GEO
TranscriptomicsSenescence defines a distinct subset of myofibroblasts that orchestrates immunosuppression in pancreatic cancer
Therapeutic resistance in PDAC is largely attributed to a unique tumor microenvironment embedded with an abundance of cancer associated fibroblasts (CAFs). Distinct CAF populations were recently identified, but the phenotypic drivers and specific impact of CAF heterogeneity remain unclear. In this s...
ORGANISM(S): Mus musculus 
2024-03-15 | GSE254384 | GEO
TranscriptomicsSenescent cell elimination modifies features of Alzheimer’s disease in 3xTg-AD mice
Cellular senescence has been associated with neurodegenerative disease and clearance of senescent cells using genetic or pharmaceutical strategies (senolytics) has demonstrated beneficial effects in mouse models investigating individual disease etiologies of Alzheimer’s disease (AD). However, it has...
ORGANISM(S): Mus musculus 
2024-03-20 | GSE231332 | GEO
UnknownPROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer.
Not available
S-EPMC10968744 | biostudies-literature
UnknownSenescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment.
Not available
S-EPMC10948808 | biostudies-literature
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