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TranscriptomicsA Myc transcriptional program that is independent of EMT drives a poor prognosis tumor-propagating phenotype in HER2+ breast cancer
The HER2 (ERBB2) and MYC genes are commonly amplified genes in breast cancer, yet little is known about their molecular and clinical interaction. Using a novel chimeric mammary transgenic approach and in vitro models, we demonstrate markedly increased self renewal and tumour propagating capability o...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-GEOD-43730 | biostudies-arrayexpress
UnknownFruit and Vegetable Intake and Home Nutrition Environment among Low-Income Minority Households with Elementary-Aged Children.
Not available
S-EPMC10145522 | biostudies-literature
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [mouse]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Mus musculus 
2014-01-13 | E-GEOD-30406 | biostudies-arrayexpress
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-30405 | biostudies-arrayexpress
UnknownELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
Not available
S-EPMC4696735 | biostudies-literature
UnknownCare Models to Improve Pain and Reduce Opioids Among Patients Prescribed Long-Term Opioid Therapy: The VOICE Randomized Clinical Trial.
Not available
S-EPMC11791716 | biostudies-literature
UnknownImpact of postoperative acute kidney injury in patients undergoing major gastrointestinal surgery on 1-year survival and renal outcomes: a national multicentre cohort study.
Not available
S-EPMC8759520 | biostudies-literature
UnknownDeveloping trustworthy recommendations as part of an urgent response (1-2 weeks): a GRADE concept paper.
Not available
S-EPMC7526592 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
UnknownChallenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives.
Not available
S-EPMC6909648 | biostudies-literature
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